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2020
ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospitalised Patients: A structured summary of a study protocol for a randomised controlled trial
Wilkinson, T., Dixon, R., Page, C., Carroll, M., Griffiths, G., Ho, L-P., De Soyza, A., Felton, T., Lewis, K. E., Phekoo, K., Chalmers, J. D., Gordon, A., McGarvey, L., Doherty, J., Read, R. C., Shankar-Hari, M., Martinez-Alier, N., O'Kelly, M., Duncan, G., Walles, R. & 3 others, , 31 Jul 2020, In: Trials. 21, 1, 3 p., 691.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)44 Downloads (Pure) -
A cuckoo covid coincidence?
Chalmers, J. D. & Lonergan, M., 15 Oct 2020, In: European Respiratory Journal. 56, 4, 4 p., 2003236.Research output: Contribution to journal › Letter › peer-review
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A high-risk airway mycobiome is associated with frequent exacerbation and mortality in COPD
Tiew, P. Y., Dicker, A. J., Keir, H. R., Poh, M. E., Pang, S. L., Mac Aogáin, M., Chua Qi Yu, B., Tan, J. L., Xu, H., Koh, M. S., Tee, A., Abisheganaden, J. A., Chew, F. T., Miller, B. E., Tal-Singer, R., Chalmers, J. D. & Chotirmall, S. H., 24 Sep 2020, In: European Respiratory Journal.Research output: Contribution to journal › Article › peer-review
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A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition
Ulhuq, F. R., Gomes, M. C., Duggan, G. M., Guo, M., Mendonca, C., Buchanan, G., Chalmers, J. D., Cao, Z., Kneuper, H., Murdoch, S., Thomson, S., Strahl, H., Trost, M., Mostowy, S. & Palmer, T., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20836-20847 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)14 Downloads (Pure) -
Blood eosinophils as a biomarker of future COPD exacerbation risk: pooled data from 11 clinical trials
Singh, D., Wedzicha, J. A., Siddiqui, S., de la Hoz, A., Xue, W., Magnussen, H., Miravitlles, M., Chalmers, J. D. & Calverley, P. M. A., 17 Sep 2020, In: Respiratory Research. 21, 10 p., 240.Research output: Contribution to journal › Article › peer-review
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Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD
Lonergan, M., Dicker, A. J., Crichton, M. L., Keir, H. R., Van Dyke, M. K., Mullerova, H., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 1 Jul 2020, In: Respiratory Research. 21, p. 1-10 10 p., 166.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)20 Downloads (Pure) -
Changes in respiratory symptoms during 48 weeks treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies
Chalmers, J. D., Cipolla, D., Thompson, B., Davis, A. M., O'Donnell, A., Tino, G., Gonda, I., Haworth, C. & Froehlich, J., 22 Oct 2020, In: European Respiratory Journal. 55, 6, 2000110.Research output: Contribution to journal › Article › peer-review
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Characteristics and Outcomes of Health and Social Care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland
Siddiqui, M. K., Parcell, B., Allstaff, S., Palmer, C., Chalmers, J. & Bell, S., 1 Sep 2020, In: European Respiratory Journal. 56, 3, 2 p., 2002568.Research output: Contribution to journal › Letter › peer-review
Open AccessFile1 Citation (Scopus)13 Downloads (Pure) -
Clinical and financial burden of hospitalised community-acquired pneumonia in patients with selected underlying comorbidities in England
Campling, J., Jones, D., Chalmers, J., Jiang, Q., Vyse, A., Madhava, H., Ellsbury, G., Rabe, A. & Slack, M., 13 Oct 2020, In: BMJ Open Respiratory Research. 7, 1, 10 p., e000703.Research output: Contribution to journal › Article › peer-review
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Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD
Keir, H. R., Dicker, A., Lonergan, M., Crichton, M., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 1 Oct 2020, In: European Respiratory Journal. 56, 4, 2000391.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Counting the cost of bronchiectasis
Gao, Y-H. & Chalmers, J. D., 30 Jun 2020, In: Respirology . 2 p.Research output: Contribution to journal › Editorial › peer-review
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CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin
Keir, H. R., Richardson, H., Fillmore, C., Shoemark, A., Lazaar, A. L., Miller, B. E., Tal-Singer, R., Chalmers, J. D. & Mohan, D., 10 Nov 2020, In: ERJ Open Research. 6, 4, 4 p., 00583-2020.Research output: Contribution to journal › Article › peer-review
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Cystic fibrosis lung disease and bronchiectasis
Chalmers, J. D., Jan 2020, In: The Lancet Respiratory Medicine. 8, 1, p. 12-14 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Open AccessFile1 Citation (Scopus)67 Downloads (Pure) -
Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST)
Artaraz, A., Crichton, M. L., Finch, S., Abo-Leyah, H., Goeminne, P., Aliberti, S., Fardon, T. & Chalmers, J. D., 13 Jan 2020, In: Respiratory Research. 21, 1, 9 p., 18.Research output: Contribution to journal › Article › peer-review
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Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals
Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., Ballas, Z. K., Barreiro, E., Bell, S. C., Bellomo, R., Bernstein, J. A., Branson, R. D., Brusasco, V., Chalmers, J. D., Chokroverty, S., Citerio, G., Collop, N. A., Cooke, C. R., Crapo, J. D., Donaldson, G. & 19 others, , May 2020, In: Critical Care Medicine. 48, 5, p. 623-633 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)182 Downloads (Pure) -
Development of Drugs for Nontuberculous Mycobacterial Disease: Clinicians' Interpretation of a US FDA Workshop
Flume, P. A., Griffith, D. E., Chalmers, J. D., Daley, C. L., Olivier, K., O'Donnell, A., Aksamit, T., Kasperbauer, S., Leitman, A. & Winthrop, K. L., 24 Aug 2020, In: Chest.Research output: Contribution to journal › Review article › peer-review
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Drive-through testing for SARS-CoV-2 in symptomatic health and social care workers and household members: an observational cohort study
Parcell, B., Brechin, K., Allstaff, S., Park, M., Third, W., Bean, S., Hind, C., Farmer, R. & Chalmers, J. D., 1 Dec 2020, In: Thorax. 75, 12, p. 1109-1111 3 p.Research output: Contribution to journal › Article › peer-review
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Efficacy and safety of TOBI Podhaler® in Pseudomonas aeruginosa-infected bronchiectasis patients: iBEST study
Loebinger, M. R., Polverino, E., Chalmers, J. D., Tiddens, H. A. W. M., Goossens, H., Ringhausen, F. C., Tunney, M., Hill, A. T., Pathan, R., Angyalosi, G., Blasi, F., Elborn, S. J. & Haworth, C. S., 27 Aug 2020, In: European Respiratory Journal.Research output: Contribution to journal › Article › peer-review
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Estimates of the ongoing need for social distancing and control measures post-"lockdown" from trajectories of COVID-19 cases and mortality
Lonergan, M. & Chalmers, J. D., 23 Jul 2020, In: European Respiratory Journal. 56, 1, 10 p., 2001483.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)17 Downloads (Pure) -
European Respiratory Society International Congress, Madrid, 2019: nontuberculous mycobacterial pulmonary disease highlights
Chalmers, J. D., Balavoine, C., Castellotti, P. F., Hügel, C., Payet, A., Wat, D. & Rohde, G., Oct 2020, In: ERJ Open Research. 6, 4, 8 p., 00317-2020.Research output: Contribution to journal › Review article › peer-review
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Genetic and pharmacological relationship between P-Glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An Epidemiological and Genomic Population-Based Cohort Study in Scotland, UK
Mordi, I. R., Chan, B., Yanez, N. D., Palmer, C. N. A., Lang, C. C. & Chalmers, J. D., 23 Nov 2020, In: PLoS Medicine. 17, 11, 16 p., e1003372.Research output: Contribution to journal › Article › peer-review
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Happy Birthday Bronchiectasis: 200 Years of Targeting Mucus
Chalmers, J. D. & Sibila, O., 15 Mar 2020, In: American Journal of Respiratory and Critical Care Medicine. 201, 6, p. 639-640 2 p.Research output: Contribution to journal › Editorial › peer-review
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Increased Chitotriosidase Is Associated With Aspergillus and Frequent Exacerbations in South-East Asian Patients With Bronchiectasis
Poh, T. Y., Tiew, P. Y., Hou Lim, A. Y., Thng, K. X., Binte Mohamed Ali, N. A., Narayana, J. K., Aogáin, M. M., Tien, Z., Chew, W. M., Wai Chan, A. K., Keir, H. R., Dicker, A. J., Hassan, T. M., Xu, H., Tee, A. K. H., Ong, T. H., Koh, M. S., Abisheganaden, J. A., Chalmers, J. D. & Chotirmall, S. H., Aug 2020, In: Chest. 158, 2, p. 512-522 11 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Inhaled Aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a post-hoc analysis of the AIR-BX studies
Crichton, M. L., Lonergan, M., Barker, A. F., Sibila, O., Goeminne, P., Shoemark, A. & Chalmers, J. D., 16 Jul 2020, In: European Respiratory Journal. 56, 1Research output: Contribution to journal › Article › peer-review
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International perspective on the new 2019 ATS/IDSA CAP guideline - a critical appraisal by a global expert panel
Pletz, M. W., Blasi, F., Chalmers, J. D., Dela Cruz, C. S., Feldman, C., Luna, C. M., Ramirez, J. A., Shindo, Y., Stolz, D., Torres, A., Webb, B., Welte, T., Wunderink, R. & Aliberti, S., 25 Aug 2020, In: Chest. 7 p.Research output: Contribution to journal › Review article › peer-review
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Is bronchiectasis really a disease?
Shteinberg, M., Flume, P. A. & Chalmers, J. D., 31 Mar 2020, In: European Respiratory Review. 29, 155, p. 1-10 10 p., 190051.Research output: Contribution to journal › Article › peer-review
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"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies"
Ramirez, J. A., Musher, D. M., Evans, S. E., Dela Cruz, C., Crothers, K. A., Hage, C. A., Aliberti, S., Anzueto, A., Arancibia, F., Arnold, F., Azoulay, E., Blasi, F., Bordon, J., Burdette, S., Cao, B., Cavallazzi, R., Chalmers, J., Charles, P., Chastre, J., Claessens, Y-E. & 26 others, , 16 Jun 2020, In: Chest.Research output: Contribution to journal › Review article › peer-review
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Managing and preventing exacerbation of bronchiectasis
Abo-Leyah, H. & Chalmers, J. D., Apr 2020, In: Current Opinion in Infectious Diseases. 33, 2, p. 189-196 8 p.Research output: Contribution to journal › Article › peer-review
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Multiple breath washout in bronchiectasis clinical trials: is it feasible?
O'Neill, K., Ferguson, K., Cosgrove, D., Tunney, M. M., De Soyza, A., Carroll, M., Chalmers, J. D., Gatheral, T., Hill, A. T., Hurst, J. R., Johnson, C., Loebinger, M. R., Angyalosi, G., Haworth, C. S., Jensen, R., Ratjen, F., Saunders, C., Short, C., Davies, J. C., Elborn, J. S. & 1 others, , 13 Oct 2020, In: ERJ Open Research. 6, 4, 10 p., 00363-2019.Research output: Contribution to journal › Article › peer-review
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Pandemic trials: evidence-based medicine on steroids
Chalmers, J. D., Dec 2020, In: European Respiratory Journal. 56, 6, 4 p., 2004116.Research output: Contribution to journal › Article › peer-review
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Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis
Chalmers, J. D., Haworth, C. S., Metersky, M. L., Loebinger, M. R., Blasi, F., Sibila, O., O'Donnell, A. E., Sullivan, E. J., Mange, K. C., Fernandez, C., Zou, J., Daley, C. L. & WILLOW Investigators, 7 Sep 2020, In: New England Journal of Medicine. 11 p.Research output: Contribution to journal › Article › peer-review
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Providing answers to respiratory patients’ questions during covid-19
Denning, J., Powell, P. & Chalmers, J. D., 2 Dec 2020, In: Breathe. 16, 3, 4 p., 200219.Research output: Contribution to journal › Article › peer-review
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Relationship between Symptoms, Exacerbations, and Treatment Response in Bronchiectasis
Gao, Y-H., Abo Leyah, H., Finch, S., Lonergan, M., Aliberti, S., De Soyza, A., Fardon, T. C., Tino, G. & Chalmers, J. D., 15 Jun 2020, In: American Journal of Respiratory and Critical Care Medicine. 201, 12, p. 1499-1507 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Rewiring the Immune Response in COVID-19
Chalmers, J. D. & Chotirmall, S. H., 15 Sep 2020, In: American Journal of Respiratory and Critical Care Medicine. 202, 6, p. 784-786 3 p.Research output: Contribution to journal › Article › peer-review
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Serum Desmosine is Associated with Long-term All-cause and Cardiovascular Mortality in Bronchiectasis
Huang, J. T-J., Kuzmanova, E., Dicker, A. J., Keir, H. R., Finch, S., Aliberti, S., Fardon, T. C. & Chalmers, J. D., 15 Sep 2020, In: American Journal of Respiratory and Critical Care Medicine. 202, 6, p. 897-899 3 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis
Oriano, M., Gramegna, A., Terranova, L., Sotgiu, G., Sulaiman, I., Ruggiero, L., Saderi, L., Wu, B., Chalmers, J. D., Segal, L. N., Marchisio, P., Blasi, F. & Aliberti, S., 22 Oct 2020, In: European Respiratory Journal. 56, 2000769.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Sputum neutrophil elastase in bronchiectasis: a Southern European cohort study
Gramegna, A., Aliberti, S., Sibila, O., Di Francesco, C., Sotgiu, G., Perea, L., Terranova, L., Oriano, M., Pilocane, T., Saderi, L., Chalmers, J. D., Marchisio, P. & Blasi, F., 25 Jun 2020, In: European Respiratory Journal. 56, 1Research output: Contribution to journal › Article › peer-review
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The evolution of the European Respiratory Journal: ready for the new decade!
Chalmers, J. D., Reeves, E. L., Bullen, N. J. & Kolb, M., Jan 2020, In: European Respiratory Journal. 55, 1, p. 1-4 4 p., 1902503.Research output: Contribution to journal › Editorial › peer-review
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The microbiome in bronchiectasis: Cutting a lung story short
Smith, A. H. & Chalmers, J. D., 1 Jan 2020, In: Respirology . 25, 1, p. 43-44 2 p.Research output: Contribution to journal › Editorial › peer-review
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Tiotropium/Olodaterol Delays Clinically Important Deterioration Compared with Tiotropium Monotherapy in Patients with Early COPD: a Post Hoc Analysis of the TONADO® Trials
Rabe, K. F., Chalmers, J. D., Miravitlles, M., Kocks, J. W. H., Tsiligianni, I., de la Hoz, A., Xue, W., Singh, D., Ferguson, G. T. & Wedzicha, J., 11 Nov 2020, In: Advances in Therapy. 15 p.Research output: Contribution to journal › Article › peer-review
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Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020)
American Thoracic Society/European Respiratory Society Coordinated International Task Force, Bai, C., Chotirmall, S. H., Rello, J., Alba, G. A., Ginns, L. C., Krishnan, J. A., Rogers, R., Bendstrup, E., Burgel, P-R., Chalmers, J. D., Chua, A., Crothers, K. A., Duggal, A., Kim, Y. W., Laffey, J. G., Luna, C. M., Niederman, M. S., Raghu, G., Ramirez, J. A. & 38 others, , 5 Oct 2020, In: European Respiratory Review. 29, 157, 15 p., 200287.Research output: Contribution to journal › Review article › peer-review
Open AccessFile2 Citations (Scopus)6 Downloads (Pure) -
Using Airway Clearance Techniques in Bronchiectasis: Halfway There
Spinou, A. & Chalmers, J. D., Oct 2020, In: Chest. 158, 4, p. 1298-1300 3 p.Research output: Contribution to journal › Editorial › peer-review
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Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis
Carreto, L., Morrison, M., Donovan, J., Finch, S., Tan, G. L., Fardon, T., Wilson, R., Furrie, E., Loebinger, M. & Chalmers, J. D., 26 Jun 2020, In: Thorax. 75, 7, p. 592-593 2 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)28 Downloads (Pure) -
Validation of the Bronchiectasis Impact Measure (BIM) - a novel patient reported outcome measure
Crichton, M. L., Dudgeon, E. K., Shoemark, A. & Chalmers, J. D., 19 Nov 2020, In: European Respiratory Journal.Research output: Contribution to journal › Article › peer-review
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Variability in airway inflammation, symptoms, lung function and reliever use in asthma: anti-inflammatory reliever hypothesis and STIFLE study design
Harrison, T., Pavord, I. D., Chalmers, J. D., Whelan, G., Fagerås, M., Rutgersson, A., Belton, L., Siddiqui, S. & Gustafson, P., 8 Jun 2020, In: ERJ Open Research. 6, 2, p. 1-10 10 p., 00333.Research output: Contribution to journal › Article › peer-review
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Withdrawal of inhaled corticosteroids in COPD: A European Respiratory Society Guideline
Chalmers, J. D., Laska, I. F., Franssen, F. M. E., Janssens, W., Pavord, I., Rigau, D., McDonnell, M. J., Roche, N., Sin, D. D., Stolz, D., Suissa, S., Wedzicha, J. & Miravitlles, M., 1 Jun 2020, In: European Respiratory Journal. 55, 6, 12 p., 2000351.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2019
A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial
Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, , 19 Dec 2019, In: Trials. 20, 10 p., 747.Research output: Contribution to journal › Article › peer-review
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Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis
Sibila, O., Laserna, E., Shoemark, A., Keir, H. R., Finch, S., Rodrigo-Troyano, A., Perea, L., Lonergan, M., Goeminne, P. C. & Chalmers, J. D., 1 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 33-41 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)27 Downloads (Pure) -
Antimicrobial peptides, disease severity and exacerbations in bronchiectasis
Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In: Thorax. 74, 9, p. 835-842 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)204 Downloads (Pure) -
A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation
Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In: European Respiratory Journal. 53, 6, 9 p., 1900303.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)33 Downloads (Pure)