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  • James Chalmers
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2020

Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD

Keir, H. R., Dicker, A., Lonergan, M., Crichton, M., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 22 May 2020, In : European Respiratory Journal.

Research output: Contribution to journal › Article

Cystic fibrosis lung disease and bronchiectasis

Chalmers, J. D., Jan 2020, In : The Lancet Respiratory Medicine. 8, 1, p. 12-14 3 p.

Research output: Contribution to journal › Comment/debate

Open Access
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13 Downloads (Pure)

Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST)

Artaraz, A., Crichton, M. L., Finch, S., Abo-Leyah, H., Goeminne, P., Aliberti, S., Fardon, T. & Chalmers, J. D., 13 Jan 2020, In : Respiratory Research. 21, 1, p. 1-9 1 p., 18.

Research output: Contribution to journal › Article

Open Access
File
35 Downloads (Pure)

Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals

Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., Ballas, Z. K., Barreiro, E., Bell, S. C., Bellomo, R., Bernstein, J. A., Branson, R. D., Brusasco, V., Chalmers, J. D., Chokroverty, S., Citerio, G., Collop, N. A., Cooke, C. R., Crapo, J. D., Donaldson, G. & 19 others, Fitzgerald, D. A., Grainger, E., Hale, L., Herth, F. J., Kochanek, P. M., Marks, G., Moorman, J. R., Ost, D. E., Schatz, M., Sheikh, A., Smyth, A. R., Stewart, I., Stewart, P. W., Swenson, E. R., Szymusiak, R., Teboul, J-L., Vincent, J-L., Wedzicha, J. A. & Maslove, D. M., May 2020, In : Critical Care Medicine. 48, 5, p. 623-633 11 p.

Research output: Contribution to journal › Article

Open Access
File
1 Citation (Scopus)
139 Downloads (Pure)

Happy Birthday Bronchiectasis: 200 Years of Targeting Mucus

Chalmers, J. D. & Sibila, O., 15 Mar 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 6, p. 639-640 2 p.

Research output: Contribution to journal › Editorial

Open Access
File
11 Downloads (Pure)

Increased Chitotriosidase is Associated with Aspergillus and Frequent Exacerbations in South-East Asians with Bronchiectasis

Poh, T. Y., Tiew, P. Y., Hou Lim, A. Y., Thng, K. X., Binte Mohamed Ali, N. A., Narayana, J. K., Aogáin, M. M., Tien, Z., Chew, W. M., Wai Chan, A. K., Keir, H. R., Dicker, A. J., Hassan, T. M., Xu, H., Tee, A. K. H., Ong, T. H., Koh, M. S., Abisheganaden, J. A., Chalmers, J. D. & Chotirmall, S. H., 14 Mar 2020, In : Chest.

Research output: Contribution to journal › Article

Inhaled Aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a post-hoc analysis of the AIR-BX studies

Crichton, M. L., Lonergan, M., Barker, A. F., Sibila, O., Goeminne, P., Shoemark, A. & Chalmers, J. D., 7 Apr 2020, In : European Respiratory Journal.

Research output: Contribution to journal › Article

Is bronchiectasis really a disease?

Shteinberg, M., Flume, P. A. & Chalmers, J. D., 31 Mar 2020, In : European Respiratory Review. 29, 155, p. 1-10 10 p., 190051.

Research output: Contribution to journal › Article

Open Access
File
30 Downloads (Pure)

Managing and preventing exacerbation of bronchiectasis

Abo-Leyah, H. & Chalmers, J. D., Apr 2020, In : Current Opinion in Infectious Diseases. 33, 2, p. 189-196 8 p.

Research output: Contribution to journal › Article

Serum Desmosine is Associated with Long-term All-cause and Cardiovascular Mortality in Bronchiectasis

Huang, J. T-J., Kuzmanova, E., Dicker, A. J., Keir, H. R., Finch, S., Aliberti, S., Fardon, T. C. & Chalmers, J. D., 13 May 2020, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article

The evolution of the European Respiratory Journal: ready for the new decade!

Chalmers, J. D., Reeves, E. L., Bullen, N. J. & Kolb, M., Jan 2020, In : European Respiratory Journal. 55, 1, p. 1-4 4 p., 1902503.

Research output: Contribution to journal › Editorial

The microbiome in bronchiectasis: Cutting a lung story short

Smith, A. H. & Chalmers, J. D., 1 Jan 2020, In : Respirology . 25, 1, p. 43-44 2 p.

Research output: Contribution to journal › Editorial

The Relationship Between Symptoms, Exacerbations and Treatment Response in Bronchiectasis

Gao, Y-H., Abo Leyah, H., Finch, S., Lonergan, M., Aliberti, S., De Soyza, A., Fardon, T. C., Tino, G. & Chalmers, J. D., 25 Feb 2020, In : American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article

The Sputum Microbiome, Airway Inflammation and Mortality in Chronic Obstructive Pulmonary Disease

Dicker, A. J., Huang, J. T. J., Lonergan, M., Keir, H. R., Fong, C. J., Tan, B., Cassidy, A. J., Finch, S., Mullerova, H., Miller, B. E., Tal-Singer, R. & Chalmers, J. D., 28 Apr 2020, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journal › Article

Utility of routine screening for alpha-1 antitrypsin deficiency in patients with bronchiectasis

Carreto, L., Morrison, M., Donovan, J., Finch, S., Tan, G. L., Fardon, T., Wilson, R., Furrie, E., Loebinger, M. & Chalmers, J. D., 17 Apr 2020, In : Thorax. 2 p., 2019-214195.

Research output: Contribution to journal › Article

Open Access
File
8 Downloads (Pure)

Withdrawal of Inhaled Corticosteroids in Chronic Obstructive Pulmonary Disease: A European Respiratory Society Guideline

Chalmers, J. D., Laska, I. F., Franssen, F. M. E., Janssens, W., Pavord, I., Rigau, D., McDonnell, M. J., Roche, N., Sin, D. D., Stolz, D., Suissa, S., Wedzicha, J. & Miravitlles, M., 4 May 2020, In : European Respiratory Journal. 53 p.

Research output: Contribution to journal › Article

2019

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, Elborn, S., 19 Dec 2019, In : Trials. 20, 1, p. 1-10 10 p., 747.

Research output: Contribution to journal › Article

Open Access
File
32 Downloads (Pure)

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Sibila, O., Laserna, E., Shoemark, A., Keir, H. R., Finch, S., Rodrigo-Troyano, A., Perea, L., Lonergan, M., Goeminne, P. C. & Chalmers, J. D., 1 Jul 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 33-41 9 p.

Research output: Contribution to journal › Article

Open Access
File
10 Citations (Scopus)
3 Downloads (Pure)

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In : Thorax. 74, 9, p. 835-842 8 p.

Research output: Contribution to journal › Article

Open Access
File
2 Citations (Scopus)
171 Downloads (Pure)

A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In : European Respiratory Journal. 53, 6, 1900303.

Research output: Contribution to journal › Article

Open Access
File
2 Citations (Scopus)
4 Downloads (Pure)

A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults

Crichton, M. L., Aliberti, S. & Chalmers, J. D., 31 Mar 2019, In : European Respiratory Review. 28, 151, p. 1-14 14 p., 180108.

Research output: Contribution to journal › Review article

Open Access
File
3 Citations (Scopus)
126 Downloads (Pure)

British Thoracic Society Guideline for bronchiectasis in adults

Hill, A. T., Sullivan, A. L., Chalmers, J. D., De Soyza, A., Elborn, J. S., Floto, R. A., Grillo, L., Gruffydd-Jones, K., Harvey, A., Haworth, C. S., Hiscocks, E., Hurst, J. R., Johnson, C., Kelleher, W. P., Bedi, P., Payne, K., Saleh, H., Screaton, N. J., Smith, M., Tunney, M. & 3 others, Whitters, D., Wilson, R. & Loebinger, M. R., Jan 2019, In : Thorax. 74, Suppl 1, p. 1-69 69 p., 74.

Research output: Contribution to journal › Article

Open Access
File
37 Citations (Scopus)
86 Downloads (Pure)

Bronchiectasis in India: results from the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) and Respiratory Research Network of India Registry

Dhar, R., Singh, S., Talwar, D., Mohan, M., Tripathi, S. K., Swarnakar, R., Trivedi, S., Rajagopala, S., D'Souza, G., Padmanabhan, A., Baburao, A., Mahesh, P. A., Ghewade, B., Nair, G., Jindal, A., Jayadevappa, G. D. H., Sawhney, H., Sarmah, K. R., Saha, K., Anantharaj, S. & 44 others, Khanna, A., Gami, S., Shah, A., Shah, A., Dutt, N., Garg, H., Vyas, S., Venugopal, K., Prasad, R., Aleemuddin, N. M., Karmakar, S., Singh, V., Jindal, S. K., Sharma, S., Prajapat, D., Chandrashekaria, S., McDonnell, M. J., Mishra, A., Rutherford, R., Ramanathan, R. P., Goeminne, P. C., Vasudev, P., Dimakou, K., Crichton, M. L., Jayaraj, B. S., Kungwani, R., Das, A., Sawhney, M., Polverino, E., Torres, A., Gulecha, N. S., Shteinberg, M., De Soyza, A., Mangala, A., Shah, P., Chauhan, N. K., Jajodia, N., Singhal, A., Batra, S., Hasan, A., Limaye, S., Salvi, S., Aliberti, S. & Chalmers, J. D., 1 Sep 2019, In : The Lancet Global Health. 7, 9, p. e1269-e1279 11 p.

Research output: Contribution to journal › Article

Open Access
File
6 Citations (Scopus)
65 Downloads (Pure)

Bronchiectasis insanity: Doing the same thing over and over again and expecting different results?

Metersky, M. & Chalmers, J., 15 Mar 2019, In : F1000Research. 8, p. 1-7 7 p., 293.

Research output: Contribution to journal › Review article

Open Access
File
1 Citation (Scopus)
96 Downloads (Pure)

Challenges in severe community-acquired pneumonia: a point-of-view review

Torres, A., Chalmers, J. D., Dela Cruz, C. S., Dominedò, C., Kollef, M., Martin-Loeches, I., Niederman, M. & Wunderink, R. G., Feb 2019, In : Intensive Care Medicine. 45, 2, p. 159-171 13 p.

Research output: Contribution to journal › Review article

7 Citations (Scopus)

Control of Confounding and Reporting of Results in Causal Inference Studies: Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals

Lederer, D. J., Bell, S. C., Branson, R. D., Chalmers, J. D., Marshall, R., Maslove, D. M., Ost, D. E., Punjabi, N. M., Schatz, M., Smyth, A. R., Stewart, P. W., Suissa, S., Adjei, A. A., Akdis, C. A., Azoulay, É., Bakker, J., Ballas, Z. K., Bardin, P. G., Barreiro, E., Bellomo, R. & 28 others, Bernstein, J. A., Brusasco, V., Buchman, T. G., Chokroverty, S., Collop, N. A., Crapo, J. D., Fitzgerald, D. A., Hale, L., Hart, N., Herth, F. J., Iwashyna, T. J., Jenkins, G., Kolb, M., Marks, G. B., Mazzone, P., Moorman, J. R., Murphy, T. M., Noah, T. L., Reynolds, P., Riemann, D., Russell, R. E., Sheikh, A., Sotgiu, G., Swenson, E. R., Szczesniak, R., Szymusiak, R., Teboul, J-L. & Vincent, J-L., Jan 2019, In : Annals of the American Thoracic Society. 16, 1, p. 22-28 7 p.

Research output: Contribution to journal › Article

Open Access
File
92 Citations (Scopus)
335 Downloads (Pure)

Distinct 'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis

Mac Aogáin, M., Tiew, P. Y., Lim, A. Y. H., Low, T. B., Tan, G. L., Hassan, T., Ong, T. H., Pang, S. L., Lee, Z. Y., Gwee, X. W., Martinus, C., Sio, Y. Y., Matta, S. A., Ong, T. C., Tiong, Y. S., Wong, K. N., Narayanan, S., Bijin Au, V., Marlier, D., Keir, H. R. & 8 others, Tee, A., Abisheganaden, J. A., Koh, M. S., Wang, D. Y., Connolly, J. E., Chew, F. T., Chalmers, J. D. & Chotirmall, S. H., 1 Apr 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 7, p. 842-853 12 p.

Research output: Contribution to journal › Article

Open Access
File
15 Citations (Scopus)
167 Downloads (Pure)

Efficacy and safety of tobramycin inhalation powder in bronchiectasis patients with P. aeruginosa infection: Design of a dose-finding study (iBEST-1)

Oct 2019, In : Pulmonary Pharmacology & Therapeutics. 58, 29 p., 101834.

Research output: Contribution to journal › Article

Evaluation of active neutrophil elastase in sputum of bronchiectasis and cystic fibrosis patients: A comparison among different techniques

Oriano, M., Terranova, L., Sotgiu, G., Saderi, L., Bellofiore, A., Retucci, M., Marotta, C., Gramegna, A., Miglietta, D., Carnini, C., Marchisio, P., Chalmers, J. D., Aliberti, S. & Blasi, F., Dec 2019, In : Pulmonary Pharmacology & Therapeutics. 59, p. 1-6 6 p., 101856.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Ewig, S., Kolditz, M., Pletz, M. W. & Chalmers, J., Oct 2019, In : Clinical Microbiology and Infection. 25, 10, p. 1173-1179 7 p.

Research output: Contribution to journal › Review article

3 Citations (Scopus)

Improving anti-fungal stewardship and the management of chronic pulmonary aspergillosis through a complex lung infection MDT

Browne, A., Wilkie, M., Waqar, A., Shaw, A., Hill, K., Rae, N., Chalmers, J., Fardon, T. & Connell, D., 12 Nov 2019.

Research output: Contribution to conference › Abstract

Open Access

Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase 3, randomised controlled trials

Haworth, C. S., Bilton, D., Chalmers, J. D., Davis, A. M., Froehlich, J., Gonda, I., Thompson, B., Wanner, A. & O'Donnell, A. E., Mar 2019, In : The Lancet Respiratory Medicine. 7, 3, p. 213-226 14 p.

Research output: Contribution to journal › Article

Open Access
File
26 Citations (Scopus)
244 Downloads (Pure)

Intermittent prophylactic antibiotics for bronchiectasis

Spencer, S., Donovan, T., Chalmers, J. D., Mathioudakis, A. G., Mcdonnell, M. J., Tsang, A. & Pilkington, G., 31 Jan 2019, In : Cochrane Database of Systematic Reviews. 2019, 1, 15 p., CD013254.

Research output: Contribution to journal › Article

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis

Chalmers, J. D., Boersma, W., Lonergan, M., Jayaram, L., Crichton, M. L., Karalus, N., Taylor, S. L., Martin, M. L., Burr, L. D., Wong, C. & Altenburg, J., Oct 2019, In : The Lancet Respiratory Medicine. 7, 10, p. 845-854 10 p.

Research output: Contribution to journal › Article

Open Access
File
7 Citations (Scopus)
69 Downloads (Pure)

Microbiological changes observed over 48 weeks of treatment with inhaled liposomal ciprofloxacin in individuals with non-cystic fibrosis bronchiectasis and chronic Pseudomonas aeruginosa lung infection

VanDevanter, D. R., Gonda, I., Dahms, J., Cipolla, D., Davis, A. M., Chalmers, J. D. & Froehlich, J., Dec 2019, In : Clinical Microbiology and Infection. 25, 12, p. 1532-1538 7 p.

Research output: Contribution to journal › Article

2 Citations (Scopus)

Personalised anti-inflammatory therapy for bronchiectasis and cystic fibrosis: selecting patients for controlled trials of neutrophil elastase inhibition

Keir, H. R., Fong, C. J., Crichton, M. L., Barth, P., Chevalier, E., Brady, G., Kennedy, G., Zimmermann, J., Bruijnzeel, P. L. B., Dicker, A. J. & Chalmers, J. D., 1 Feb 2019, In : ERJ Open Research. 5, 1, p. 1-9 9 p., 00252-2018.

Research output: Contribution to journal › Article

Open Access
File
103 Downloads (Pure)

Plasma desmosine, an elastin degradation product, predicts outcomes in at risk populations

Iskandar, Z., Mordi, I., Huang, J. T. J., Newby, D., Chalmers, J., Bown, M., Lang, C. & Choy, A. M., 12 Mar 2019, In : Journal of the American College of Cardiology. 73, 9, Supplement 1, p. 1805 1 p.

Research output: Contribution to journal › Article

Pregnancy Zone Protein is Associated with Airway Infection, Neutrophil Extracellular Trap Formation and Disease Severity in Bronchiectasis

Finch, S., Shoemark, A., Dicker, A. J., Keir, H. R., Smith, A., Ong, S., Tan, B., Choi, J., Fardon, T. C., Cassidy, D., Huang, J. T. J. & Chalmers, J. D., 15 Oct 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 8, p. 992-1001 10 p.

Research output: Contribution to journal › Article

Open Access
File
1 Citation (Scopus)
128 Downloads (Pure)

Pulmonary Rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial

Chalmers, J. D., Crichton, M. L., Brady, G., Finch, S., Lonergan, M. & Fardon, T., 6 May 2019, In : BMC Pulmonary Medicine. 19, p. 1-9 9 p., 85.

Research output: Contribution to journal › Article

Open Access
File
1 Citation (Scopus)
103 Downloads (Pure)

Recomendaciones de las guías de bronquiectasias llevadas a la práctica clínica

Translated title of the contribution: Bronchiectasis Guidelines-Recommendations Into PracticeRedondo, M. & Chalmers, J. D., Jun 2019, In : Archivos de Bronconeumologia. 55, 6, p. 286-288 3 p.

Research output: Contribution to journal › Editorial

Recomendaciones de las guías de bronquiectasias llevadas a la práctica clínica

Translated title of the contribution: Bronchiectasis Guidelines-Recommendations Into PracticeRedondo, M. & Chalmers, J. D., 1 Jun 2019, In : Archivos de Bronconeumologia. 55, 6, p. 286-288 3 p.

Research output: Contribution to journal › Editorial

1 Citation (Scopus)

Recommendations for travelling with bronchiectasis: a joint ELF/EMBARC/ERN-Lung collaboration

Shteinberg, M., Crossley, B., Lavie, T., Nadler, S., Boyd, J., Ringshausen, F. C., Aksamit, T., Chalmers, J. D. & Goeminne, P., Oct 2019, In : ERJ Open Research. 5, 4, p. 1-22 22 p., 00113-2019.

Research output: Contribution to journal › Article

Open Access
File
56 Downloads (Pure)

Reply: More on causal inference studies

Lederer, D. J., Bell, S. C., Smyth, A. R. & Chalmers, J. D., 1 May 2019, In : Annals of the American Thoracic Society. 16, 5, p. 646 1 p.

Research output: Contribution to journal › Letter

Open Access
File
83 Downloads (Pure)

Respiratory physiotherapy in the bronchiectasis guidelines: is there a loud voice we are yet to hear?

Spinou, A. & Chalmers, J. D., 28 Sep 2019, In : The European respiratory journal. 54, 3, p. 1-6 6 p., 1901610.

Research output: Contribution to journal › Editorial

Response

Chalmers, J. D., Jun 2019, In : Chest. 155, 6, p. 1302-1303 2 p.

Research output: Contribution to journal › Letter

Rheumatoid arthritis-associated bronchiectasis - Authors' reply

Flume, P. A., Chalmers, J. D. & Olivier, K. N., 18 May 2019, In : Lancet. 393, 10185, p. 2036 1 p.

Research output: Contribution to journal › Letter

2 Citations (Scopus)

Same meat, different gravy: ignore the new names of mycobacteria

Tortoli, E., Brown-Elliott, B. A., Chalmers, J. D., Cirillo, D. M., Daley, C. L., Emler, S., Floto, R. A., Garcia, M. J., Hoefsloot, W., Koh, W-J., Lange, C., Loebinger, M., Maurer, F. P., Morimoto, K., Niemann, S., Richter, E., Turenne, C. Y., Vasireddy, R., Vasireddy, S., Wagner, D. & 3 others, Wallace, R. J., Wengenack, N. & van Ingen, J., 11 Jul 2019, In : The European respiratory journal. 54, 1, p. 1-3 3 p., 1900795.

Research output: Contribution to journal › Editorial

Single-inhaler triple therapy in patients with chronic obstructive pulmonary disease: a systematic review

Langham, S., Lewis, J., Pooley, N., Embleton, N., Langham, J., Han, M. K. & Chalmers, J. D., 4 Nov 2019, In : Respiratory Research. 20, p. 1-13 13 p., 242.

Research output: Contribution to journal › Review article

Open Access
File
70 Downloads (Pure)

The economic burden of bronchiectasis - known and unknown: a systematic review

Goeminne, P. C., Hernandez, F., Diel, R., Filonenko, A., Hughes, R., Juelich, F., Solomon, G. M., Upton, A., Wichmann, K., Xu, W. & Chalmers, J. D., 28 Feb 2019, In : BMC Pulmonary Medicine. 19, 1, p. 1-11 11 p., 54.

Research output: Contribution to journal › Article

Open Access
File
5 Citations (Scopus)
116 Downloads (Pure)

The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis

Laska, I. F., Crichton, M. L., Shoemark, A. & Chalmers, J. D., Oct 2019, In : The Lancet Respiratory Medicine. 7, 10, p. 855-869 15 p.

Research output: Contribution to journal › Article

Open Access
File
6 Citations (Scopus)
24 Downloads (Pure)