A 10-year Review of Surgical Management of Dermatofibrosarcoma Protuberans

A. Durack (Lead / Corresponding author), S. Gran, M. D. Gardiner, A. Jain, E. Craythorne, C. M. Proby, J. Marsden, C A Harwood, R N Matin,

Research output: Contribution to journalArticle

Abstract

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurrence rate.

Objectives: We undertook a retrospective comparative review of DFSP surgical management in the UK National Health Service (NHS) in order to define:

1. current surgical practice for primary and recurrent DFSP
2. local recurrence rates for primary DFSP
3. survival outcomes for DFSP.

Methods: Retrospective clinical case-note review of patients with histologically-confirmed DFSP (January 2004-2014) who have undergone surgical treatment.

Results: Surgical management of 483 primary and 64 recurrent DFSP in 11 plastic surgery and 15 dermatology departments was analysed. Almost 75% of primary DFSP (n=362) were treated with WLE and 20.1% (n=97) with MMS. For recurrent DFSP, 68.7% (n=44) and 23.4% (n=15) underwent WLE and MMS, respectively. Recurrent primary DFSP occurred in 6 patients after WLE and none after MMS. Median follow-up was 4.8 years [IQR 3.5, 5.8] with 8 reported deaths during the follow-up analysis period; one confirmed to be DFSP-related.

Conclusions: WLE was the commonest surgical modality used to treat DFSP across the UK. The local recurrence rate was very low, occurring only after WLE. Although a prospective RCT may provide more definitive outcomes, in the absence of a clearly superior surgical modality, treatment decisions should be based on patient preference, clinical expertise and cost.

Original languageEnglish
JournalBritish Journal of Dermatology
DOIs
Publication statusE-pub ahead of print - 29 Jun 2020

Fingerprint Dive into the research topics of 'A 10-year Review of Surgical Management of Dermatofibrosarcoma Protuberans'. Together they form a unique fingerprint.

  • Cite this

    Durack, A., Gran, S., Gardiner, M. D., Jain, A., Craythorne, E., Proby, C. M., Marsden, J., Harwood, C. A., Matin, R. N. (2020). A 10-year Review of Surgical Management of Dermatofibrosarcoma Protuberans. British Journal of Dermatology. https://doi.org/10.1111/bjd.19346