A 12-year follow-up study of all-cause and cardiovascular mortality among 10 532 people newly diagnosed with Type 2 diabetes in Tayside, Scotland

K. N. Barnett, S. A. Ogston, M. E. T. McMurdo, A. D. Morris, J. M. M. Evans (Lead / Corresponding author)

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    Abstract

    Aims To determine absolute and relative risks of all-cause and cardiovascular mortality among patients newly diagnosed with Type 2 diabetes.

    Methods In an observational cohort study using record-linkage databases, based in Tayside, Scotland, UK, we identified newly diagnosed patients with Type 2 diabetes in 1993-2004. We also identified a set of non-diabetic comparators from lists of patients registered with a general practice, individually matched to the diabetic patients by sex, age and deprivation. We followed up patients for mortality and cardiovascular mortality over a 12-year period and calculated hazard ratios using Cox regression.

    Results There were 10 532 patients with Type 2 diabetes and 21 056 non-diabetic comparators. Diabetic patients in every age/sex group had higher absolute mortality rates. Even taking deprivation into account, the hazard ratio for mortality was 1.32 (95% CI 1.25-1.40), decreasing to 1.15 (1.09-1.22) after adjusting for pre-existing cardiovascular disease. The hazard ratios for cardiovascular mortality were higher, decreasing from 1.51 (1.37-1.67) to 1.23 (1.11-1.36) after adjusting for pre-existing cardiovascular disease. The hazard ratios decreased with increasing age at diagnosis, although the difference in absolute rate of mortality increased slightly with age. Increased mortality risks were only evident 2 years after diagnosis and increased thereafter.

    Conclusions Patients with Type 2 diabetes have an increased risk of all-cause and cardiovascular mortality compared with non-diabetic comparators, although this is not observable immediately after diagnosis. Age at diagnosis and duration of the disease independently affect absolute and relative mortality risk.

    Original languageEnglish
    Pages (from-to)1124-1129
    Number of pages6
    JournalDiabetic Medicine
    Volume27
    Issue number10
    DOIs
    Publication statusPublished - 2010

    Keywords

    • cardiovascular mortality
    • epidemiology
    • mortality
    • risk
    • type 2 diabetes
    • CORONARY-HEART-DISEASE
    • PROSPECTIVE COHORT
    • MELLITUS
    • RISK
    • POPULATION
    • WOMEN
    • PREVALENCE
    • IMPACT
    • MEN
    • METAANALYSIS

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