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A blood-based marker of mitochondrial DNA damage in Parkinson's disease
Rui Qi
,
Esther Sammler
, Claudia P. Gonzalez-Hunt
, Ivana Barraza
, Nicholas Pena
, Jeremy P. Rouanet
, Yahaira Naaldijk
, Steven Goodson
, Marie Fuzzati
, Fabio Blandini
, Kirk I. Erickson
, Andrea M. Weinstein
, Michael W. Lutz
, John B. Kwok
, Glenda M. Halliday
, Nicolas Dzamko
, Shalini Padmanabhan
, Roy N. Alcalay
, Cheryl Waters
, Penelope Hogarth
Tanya Simuni, Danielle Smith, Connie Marras,
Francesca Tonelli
,
Dario R. Alessi
, Andrew B. West, Sruti Shiva, Sabine Hilfiker, Laurie H. Sanders (Lead / Corresponding author)
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MRC PPU
Research output
:
Contribution to journal
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Article
›
peer-review
59
Citations (Scopus)
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Keyphrases
Age-matched
10%
Blood-based Marker
100%
Brain Cells
10%
Brain Regions
10%
Cell-derived
10%
Clinical Trials
10%
Disease-associated
10%
Disease-modifying Therapy
20%
DNA Lesions
10%
G2019S Knock-in
10%
G2019S mutation
10%
High-density Markers
10%
Idiopathic Parkinson's Disease
20%
Kinase Inhibitor
10%
Knock-in Mouse Model
10%
Leucine-rich Repeat Kinase 2 (LRRK2)
60%
Lymphoblastoid Cell Lines
10%
Mitochondrial DNA
10%
Mitochondrial DNA Damage
100%
Mitochondrial Dysfunction
10%
MITOS
20%
Mutation Carriers
10%
Neurodegenerative Movement Disorder
10%
Neuron Model
10%
Neuronal Culture
10%
Neuroprotective
10%
Parkinson Patients
10%
Parkinson's Disease
100%
Parkinson's Disease Diagnosis
10%
Patient-derived
10%
Peripheral Blood Mononuclear Cells
10%
Pharmacodynamic Response
10%
Postmortem Tissue
10%
QPCR Assay
10%
Real-time Quantification
10%
Rotenone
10%
Scalable Platform
10%
Shared Etiology
10%
Small Molecule Kinase Inhibitors
10%
Ventral Midbrain
10%
Biochemistry, Genetics and Molecular Biology
Animal Model
9%
Clinical Trial
9%
DNA Damage
100%
Kinase
54%
Knockout Mouse
9%
Leucine-Rich Repeat
36%
Mitochondrial Disorder
9%
Mitochondrial DNA
100%
Nerve Cell Culture
9%
Peripheral Blood Mononuclear Cell
9%
Pharmacodynamics
9%
Phosphotransferase
54%
Rotenone
9%
Small Molecule
9%
Wild Type
9%
Neuroscience
Cell Line
8%
DNA Damage
100%
Kinase
16%
Leucine Rich Repeat Kinase 2
33%
Midbrain
16%
Mitochondrial DNA
100%
Neuroprotective Agent
8%
Parkinson's Disease
100%
Peripheral Blood Mononuclear Cell
8%
Rotenone
8%
Stereotypic Movement Disorder
8%
Pharmacology, Toxicology and Pharmaceutical Science
Clinical Trial
8%
Diseases
25%
Knockout Mouse
8%
Leucine Rich Repeat Kinase 2
33%
Mitochondrial DNA
100%
Motor Dysfunction
8%
Neuroprotective Agent
8%
Parkinson's Disease
100%
Pharmacodynamics
8%
Phosphotransferase Inhibitor
16%
Rotenone
8%