A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients

C. M. Proby (Lead / Corresponding author), C. A. Harwood, R. E. Neale, A. C. Green, S. Euvrard, L. Naldi, G. Tessari, M. C. W. Feltkamp, M. N. C. De Koning, W. G. V. Quint, T. Waterboer, M. Pawlita, S. Weissenborn, U. Wieland, H. Pfister, E. Stockfleth, I. Nindl, D. Abeni, J. ter Schegget, J. N. Bouwes BavinckEPI-HPV-UV-CA Grp

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    Abstract

    We examined the association between betapapillomavirus (betaPV) infection and cutaneous squamous cell carcinoma (SCC) in organ transplant recipients. A total of 210 organ transplant recipients with previous SCC and 394 controls without skin cancer were included. The presence of 25 betaPV types in plucked eyebrow hairs was determined using a human papillomavirus (HPV) DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types were detected using multiplex serology. We used multivariate logistic regression models to estimate associations between various measures of betaPV infection and SCC. BetaPV DNA was highly prevalent (> 94%) with multiple types frequently detected in both groups. We found a significant association between SCC and the concordant detection of both antibodies and DNA for at least one betaPV type (adjusted OR 1.6; 95% CI 1.1;2.5). A borderline-significant association with SCC was found for HPV36 (adjusted OR 2.4; CI 1.0; 5.4), with similar associations for HPV5, HPV9 and HPV24. These data provide further evidence of an association between betaPV infection and SCC in

    Original languageEnglish
    Pages (from-to)1498-1508
    Number of pages11
    JournalAmerican Journal of Transplantation
    Volume11
    Issue number7
    DOIs
    Publication statusPublished - Jul 2011

    Keywords

    • Betapapillomavirus
    • case-control study
    • cutaneous squamous cell carcinoma
    • organ transplant recipient
    • HUMAN-PAPILLOMAVIRUS TYPES
    • NONMELANOMA SKIN-CANCER
    • BETA-HUMAN PAPILLOMAVIRUSES
    • EPIDERMODYSPLASIA-VERRUCIFORMIS
    • IMMUNOCOMPETENT INDIVIDUALS
    • ACTINIC KERATOSES
    • NATIONWIDE COHORT
    • E6 PROTEINS
    • DNA
    • RISK

    Cite this

    Proby, C. M., Harwood, C. A., Neale, R. E., Green, A. C., Euvrard, S., Naldi, L., Tessari, G., Feltkamp, M. C. W., De Koning, M. N. C., Quint, W. G. V., Waterboer, T., Pawlita, M., Weissenborn, S., Wieland, U., Pfister, H., Stockfleth, E., Nindl, I., Abeni, D., ter Schegget, J., ... EPI-HPV-UV-CA Grp (2011). A Case-Control Study of Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients. American Journal of Transplantation, 11(7), 1498-1508. https://doi.org/10.1111/j.1600-6143.2011.03589.x