A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: the role of antibodies against human papillomavirus and other risk factors

Delphine Casabonne (Lead / Corresponding author), Aoife Lally, Liza Mitchell, Kristina M. Michael, Tim Waterboer, Michael Pawlita, Beata Imko-Walczuk, Fenella Wojnarowska, Charlotte Proby, Catherine Harwood, Robert Newton

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    21 Citations (Scopus)

    Abstract

    A case-control study was conducted in 140 people with histology proven cutaneous squamous cell carcinoma (SCC) and 454 controls, nested within 2 cohorts of organ transplant recipients (OTR) recruited in London and Oxford between 2002 and 2006. All participants had a skin examination, completed a questionnaire and had serum tested for antibodies against the L1 antigen of 34 HPV types using Luminex technology. SCC was more common in men than women (odds ratio [OR] = 1.7, 95% confidence interval [CI]: 1.1-2.8, p = 0.02) and in people with susceptibility to burn easily (OR = 3.0, 95%CI: 1.9-4.8; p < 0.001). The risk increased with increasing age (p-trend < 0.001), increasing time since transplant (p-trend < 0.001), increasing self-reported number of sunburns as a child (p(trend) < 0.001) and with the presence of viral warts (p < 0.001). As expected, antibodies against HPV 16 were associated with a self-reported history of an abnormal cervical smear among women (OR 5.1, 95%CI: 2.6-10.2) and antibodies against HPV 6 were associated with a self-reported history of genital warts (OR 4.0, 95%CI: 2.2-7.2). However, no clear associations between any of the HPV types examined (including cutaneous betaHPVs) and SCC were identified. For example, the seroprevalence of HPV 5 was 15% among cases and 9% among controls (p = 0.09) and the seroprevalence of HPV 8 was 23% among cases and 21% among controls (p = 0.6). Nor was seropositivity to multiple types associated with SCC. These serological data do not provide evidence for a role for HPV in the aetiology of cutaneous SCC among OTR in two UK-based populations. (C) 2009 UICC

    Original languageEnglish
    Pages (from-to)1935-1945
    Number of pages11
    JournalInternational Journal of Cancer
    Volume125
    Issue number8
    Early online date14 Apr 2009
    DOIs
    Publication statusPublished - 15 Oct 2009

    Keywords

    • Epidemiology
    • human papillomavirus (HPV)
    • serology
    • cutaneous squamous cell carcinoma (SCC)
    • organ transplant recipients
    • NONMELANOMA SKIN-CANCER
    • GLUTATHIONE-S-TRANSFERASE
    • VIRUS-LIKE PARTICLES
    • ACTINIC KERATOSES
    • IMMUNOCOMPETENT INDIVIDUALS
    • INFECTION
    • HPV
    • PREVALENCE
    • PROTEINS
    • DNA

    Research Output

    • 21 Citations
    • 1 Article

    Erratum - A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: The role of antibodies against human papillomavirus and other risk factors

    Casabonne, D., Lally, A., Mitchell, L., Michael, K. M., Waterboer, T., Pawlita, M., Imko-Walczuk, B., Wojnarowska, F., Proby, C., Harwood, C. & Newton, R., 1 Mar 2010, In : International Journal of Cancer. 126, 5, p. 1282 1 p.

    Research output: Contribution to journalArticle

    Cite this

    Casabonne, D., Lally, A., Mitchell, L., Michael, K. M., Waterboer, T., Pawlita, M., Imko-Walczuk, B., Wojnarowska, F., Proby, C., Harwood, C., & Newton, R. (2009). A case-control study of cutaneous squamous cell carcinoma among Caucasian organ transplant recipients: the role of antibodies against human papillomavirus and other risk factors. International Journal of Cancer, 125(8), 1935-1945. https://doi.org/10.1002/ijc.24511