A clock-work somite

Kim J. Dale, Olivier Pourquié (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    90 Citations (Scopus)


    Somites are transient structures which represent the most overt segmental feature of the vertebrate embryo. The strict temporal regulation of somitogenesis is of critical developmental importance since many segmental structures adopt a periodicity based on that of the somites. Until recently, the mechanisms underlying the periodicity of somitogenesis were largely unknown. Based on the oscillations of c-hairy1 and lunatic fringe RNA, we now have evidence for an intrinsic segmentation clock in presomitic cells. Translation of this temporal periodicity into a spatial periodicity, through somite formation, requires Notch signaling. While the Hox genes are certainly involved, it remains unknown how the metameric vertebrate axis becomes regionalized along the antero-posterior (AP) dimension into the occipital, cervical, thoracic, lumbar, and sacral domains. We discuss the implications of cell division as a clock mechanism underlying the regionalization of somites and their derivatives along the AP axis. Possible links between the segmentation clock and axial regionalization are also discussed.

    Original languageEnglish
    Pages (from-to)72-83
    Number of pages12
    Issue number1
    Publication statusPublished - 24 Jan 2000

    ASJC Scopus subject areas

    • General Biochemistry,Genetics and Molecular Biology


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