TY - JOUR
T1 - A CMOS SPAD Line Sensor with Per-Pixel Histogramming TDC for Time-Resolved Multispectral Imaging
AU - Erdogan, Ahmet T.
AU - Walker, Richard
AU - Finlayson, Neil
AU - Krstajic, Nikola
AU - Williams, Gareth
AU - Girkin, John
AU - Henderson, Robert
PY - 2019/6
Y1 - 2019/6
N2 - A 512 × 16 single photon avalanche diode (SPAD)-based line sensor is designed in a 0.13-$μ m CMOS image sensor technology for time-resolved multispectral beam scanned imaging. The sensor has 23.78-μ m pixel pitch and incorporates one SPAD array with 49.31% fill factor optimized for detection in the blue-green spectral region, and a second array at 15.75% fill factor optimized for the red-near-infrared response spectral region. Each pixel contains a 32-bin histogramming time-to-digital converter (TDC) with a mean time resolution of 51.20 ps. Histogram bin resolutions are adjustable from 51.20 ps to 6.55 ns per bin. The line sensor can operate in single photon counting (SPC) mode (102.1 giga-events/s), time-correlated SPC (TCSPC) mode (192.4 million-events/s) or on-chip histogramming mode (16.5 giga-events/s), increasing the count rate up to 85 times compared to TCSPC mode. Sensor capability is demonstrated through spectral fluorescence lifetime imaging, resolving three fluorophore populations with distinct fluorophore lifetimes.
AB - A 512 × 16 single photon avalanche diode (SPAD)-based line sensor is designed in a 0.13-$μ m CMOS image sensor technology for time-resolved multispectral beam scanned imaging. The sensor has 23.78-μ m pixel pitch and incorporates one SPAD array with 49.31% fill factor optimized for detection in the blue-green spectral region, and a second array at 15.75% fill factor optimized for the red-near-infrared response spectral region. Each pixel contains a 32-bin histogramming time-to-digital converter (TDC) with a mean time resolution of 51.20 ps. Histogram bin resolutions are adjustable from 51.20 ps to 6.55 ns per bin. The line sensor can operate in single photon counting (SPC) mode (102.1 giga-events/s), time-correlated SPC (TCSPC) mode (192.4 million-events/s) or on-chip histogramming mode (16.5 giga-events/s), increasing the count rate up to 85 times compared to TCSPC mode. Sensor capability is demonstrated through spectral fluorescence lifetime imaging, resolving three fluorophore populations with distinct fluorophore lifetimes.
KW - CMOS
KW - fluorescence lifetime imaging microscopy (FLIM)
KW - histogramming
KW - single photon avalanche diode (SPAD)
KW - single photon counting (SPC)
KW - time-correlated SPC (TCSPC)
KW - time-resolved spectroscopy
UR - https://www.research.ed.ac.uk/portal/en/publications/a-cmos-spad-line-sensor-with-perpixel-histogramming-tdc-for-timeresolved-multispectral-imaging(3b09d88e-5e42-49ed-bd85-c54d1261fcc0).html
UR - http://www.scopus.com/inward/record.url?scp=85066115729&partnerID=8YFLogxK
U2 - 10.1109/JSSC.2019.2894355
DO - 10.1109/JSSC.2019.2894355
M3 - Article
AN - SCOPUS:85066115729
VL - 54
SP - 1705
EP - 1719
JO - IEEE Journal of Solid-State Circuits
JF - IEEE Journal of Solid-State Circuits
SN - 0018-9200
IS - 6
M1 - 8637804
ER -
