A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation

A. D. McMahon, J. M. M. Evans, G. White, F. E. Murray, M. M. McGilchrist, D. G. McDevitt, T. M. MacDonald

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland. Exposure was classified by prescription duration. The study population consisted of the population of Tayside. A Comparator Group was chosen at random (within age and sex strata). Two hundred re-sampled comparator groups were created. Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples). The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs. There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups. The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events; univariate rate ratio = 2.76 (1.90, 4.01). The final, re-sampled estimate of NSAID risk was rate ratio = 2.48 (1.87, 3.29).

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalJournal of Clinical Epidemiology
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 1997

Fingerprint

Gastrointestinal Hemorrhage
Non-Steroidal Anti-Inflammatory Agents
Cohort Studies
Scotland
Population
Endoscopy
Ulcer
Prescriptions
Hospitalization
Pharmaceutical Preparations

Keywords

  • Cohort
  • Epidemiology
  • Hemorrhage
  • NSAID
  • Perforation
  • Re-sampling

Cite this

@article{2656d03722aa43bc9ada2d2274be035a,
title = "A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation",
abstract = "This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland. Exposure was classified by prescription duration. The study population consisted of the population of Tayside. A Comparator Group was chosen at random (within age and sex strata). Two hundred re-sampled comparator groups were created. Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples). The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs. There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups. The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events; univariate rate ratio = 2.76 (1.90, 4.01). The final, re-sampled estimate of NSAID risk was rate ratio = 2.48 (1.87, 3.29).",
keywords = "Cohort, Epidemiology, Hemorrhage, NSAID, Perforation, Re-sampling",
author = "McMahon, {A. D.} and Evans, {J. M. M.} and G. White and Murray, {F. E.} and McGilchrist, {M. M.} and McDevitt, {D. G.} and MacDonald, {T. M.}",
year = "1997",
month = "3",
doi = "10.1016/S0895-4356(96)00361-7",
language = "English",
volume = "50",
pages = "351--356",
journal = "Journal of Clinical Epidemiology",
issn = "0895-4356",
publisher = "Elsevier",
number = "3",

}

A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation. / McMahon, A. D.; Evans, J. M. M.; White, G.; Murray, F. E.; McGilchrist, M. M.; McDevitt, D. G.; MacDonald, T. M.

In: Journal of Clinical Epidemiology, Vol. 50, No. 3, 03.1997, p. 351-356.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation

AU - McMahon, A. D.

AU - Evans, J. M. M.

AU - White, G.

AU - Murray, F. E.

AU - McGilchrist, M. M.

AU - McDevitt, D. G.

AU - MacDonald, T. M.

PY - 1997/3

Y1 - 1997/3

N2 - This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland. Exposure was classified by prescription duration. The study population consisted of the population of Tayside. A Comparator Group was chosen at random (within age and sex strata). Two hundred re-sampled comparator groups were created. Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples). The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs. There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups. The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events; univariate rate ratio = 2.76 (1.90, 4.01). The final, re-sampled estimate of NSAID risk was rate ratio = 2.48 (1.87, 3.29).

AB - This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland. Exposure was classified by prescription duration. The study population consisted of the population of Tayside. A Comparator Group was chosen at random (within age and sex strata). Two hundred re-sampled comparator groups were created. Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples). The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs. There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups. The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events; univariate rate ratio = 2.76 (1.90, 4.01). The final, re-sampled estimate of NSAID risk was rate ratio = 2.48 (1.87, 3.29).

KW - Cohort

KW - Epidemiology

KW - Hemorrhage

KW - NSAID

KW - Perforation

KW - Re-sampling

U2 - 10.1016/S0895-4356(96)00361-7

DO - 10.1016/S0895-4356(96)00361-7

M3 - Article

VL - 50

SP - 351

EP - 356

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

SN - 0895-4356

IS - 3

ER -