A consensus on the use of daylight photodynamic therapy in the UK

Sally Ibbotson (Lead / Corresponding author), Robin Stones, Jonathan Bowling, Sandra Campbell, Stephen Kownack, Muthu Sivaramakrishnan, Ronan Valentine, Colin A. Morton

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Abstract

Background: Actinic keratoses (AKs) are a consequence of chronic exposure to ultraviolet radiation. Treatment of chronically photo-damaged skin and AKs is driven by risk of progression to squamous cell carcinoma, as well as for symptomatic relief. Conventional photodynamic therapy (c-PDT) is indicated when AKs are multiple or confluent and if patients respond poorly or are unable to tolerate other therapies. c-PDT is limited by the field size that can be treated in single sessions and can cause significant discomfort.

Objective: Recent studies investigated daylight illumination to activate protoporphyrin IX and daylight-PDT (d-PDT) is now licensed in the UK for face and scalp AKs. A group of experts met to discuss application of d-PDT with methyl aminolevulinate (MAL) and develop a UK consensus statement, specific to UK weather conditions.

Methods: The UK consensus recommendations were reached among eight experts, who reviewed recent studies on d-PDT, assessed UK meteorological data and discussed personal experiences of d-PDT for AKs.

Results: Recommendations from these discussions provide guidance on d-PDT use, specifically regarding patient selection, therapeutic indications, when to treat, skin preparation, MAL application and daylight exposure for patients with AKs.

Conclusions: This UK expert consensus provides practical guidance for UK application of d-PDT.
Original languageEnglish
Pages (from-to)360-367
Number of pages8
JournalJournal of Dermatological Treatment
Volume28
Issue number4
Early online date22 Sep 2016
DOIs
Publication statusPublished - 2017

Keywords

  • Actinic keratosis
  • Daylight
  • Methyl aminolevulinate
  • Photodynamic therapy

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    Ibbotson, S., Stones, R., Bowling, J., Campbell, S., Kownack, S., Sivaramakrishnan, M., Valentine, R., & Morton, C. A. (2017). A consensus on the use of daylight photodynamic therapy in the UK. Journal of Dermatological Treatment, 28(4), 360-367. https://doi.org/10.1080/09546634.2016.1240863