A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments

Nicola Luise, Eleanor W. Wyatt, Gary Tarver, Paul Wyatt (Lead / Corresponding author)

Research output: Contribution to journalArticle

Abstract

An efficient hydrogenation protocol under continuous flow conditions was developed for the synthesis of underrepresented semi-saturated bicyclic fragments containing highly sp 3-rich skeletons for fragment-based drug discovery (FBDD) programs. Excellent yields were generally achieved by using Pd/C (10 % w/w) and RaNi at 25–150 °C under 4–100 bar of hydrogen pressure. The generated fragments, with appropriate physicochemical properties, present diverse hydrogen-bonding pharmacophores and useful vectors for their synthetic elaboration in the optimization stage. Successive, simple functionalizations in continuous flow were accomplished to demonstrate the opportunity to develop multi-step continuous flow synthesis of valuable starting points for FBDD campaigns. A conclusive quality control (QC) was essential to discard those structures which do not fit the typical fragment library parameters.

LanguageEnglish
Number of pages10
JournalEuropean Journal of Organic Chemistry
Early online date7 Jan 2019
DOIs
Publication statusE-pub ahead of print - 7 Jan 2019

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fragments
synthesis
Hydrogenation
Quality control
Hydrogen
Hydrogen bonds
drugs
hydrogen
quality control
musculoskeletal system
hydrogenation
Drug Discovery
optimization

Keywords

  • Drug discovery
  • Flow reactions
  • Fused-ring systems
  • Heterocycles
  • Hydrogenation

Cite this

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