A cost-benefit analysis of the physical mechanisms of membrane curvature

Jeanne C. Stachowiak, Frances M Brodsky, Elizabeth A. Miller (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

169 Citations (Scopus)

Abstract

Many cellular membrane-bound structures exhibit distinct curvature that is driven by the physical properties of their lipid and
protein constituents. Here we review how cells manipulate and control this curvature in the context of dynamic events such as
vesicle-mediated membrane traffic. Lipids and cargo proteins each contribute energy barriers that must be overcome during
vesicle formation. In contrast, protein coats and their associated accessory proteins drive membrane bending using a variety
of interdependent physical mechanisms. We survey the energy costs and drivers involved in membrane curvature, and draw a
contrast between the stochastic contributions of molecular crowding and the deterministic assembly of protein coats. These basic
principles also apply to other cellular examples of membrane bending events, including important disease-related problems such
as viral egress.
Original languageEnglish
Pages (from-to)1019 - 1027
Number of pages9
JournalNature Cell Biology
Volume15
Issue number9
Early online date2 Sept 2013
DOIs
Publication statusPublished - 2013

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