A crowdsourcing evaluation of the NIH chemical probes

Tudor I. Oprea; Cristian G. Bologa; Scott Boyer; Ramona F. Curpan; Robert C. Glen; Andrew L. Hopkins; Christopher A. Lipinski; Garland R. Marshall; Yvonne C. Martin; Liliana Ostopovici-Halip; Gilbert Rishton; Oleg Ursu; Roy J. Vaz; Chris Waller; Herbert Waldmann; Larry A. Sklar

doi:10.1038/nchembio0709-441

A crowdsourcing evaluation of the NIH chemical probes

Tudor I. Oprea, Cristian G. Bologa, Scott Boyer, Ramona F. Curpan, Robert C. Glen, Andrew L. Hopkins, Christopher A. Lipinski, Garland R. Marshall, Yvonne C. Martin, Liliana Ostopovici-Halip, Gilbert Rishton, Oleg Ursu, Roy J. Vaz, Chris Waller, Herbert Waldmann, Larry A. Sklar

Research output: Contribution to journal › Article › peer-review

104 Citations (Scopus)

Abstract

Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Nature Chemical Biology
Volume	5
Issue number	7
DOIs	https://doi.org/10.1038/nchembio0709-441
Publication status	Published - Jul 2009

Keywords

DRUG DISCOVERY
LEAD DISCOVERY
LIBRARIES
PREDICTION
DESIGN
IDENTIFICATION
CANDIDATES

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10.1038/nchembio0709-441

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Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H., & Sklar, L. A. (2009). A crowdsourcing evaluation of the NIH chemical probes. Nature Chemical Biology, 5(7), 441-447. https://doi.org/10.1038/nchembio0709-441

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AU - Glen, Robert C.

AU - Hopkins, Andrew L.

AU - Lipinski, Christopher A.

AU - Marshall, Garland R.

AU - Martin, Yvonne C.

AU - Ostopovici-Halip, Liliana

AU - Rishton, Gilbert

AU - Ursu, Oleg

AU - Vaz, Roy J.

AU - Waller, Chris

AU - Waldmann, Herbert

AU - Sklar, Larry A.

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KW - DRUG DISCOVERY

KW - LEAD DISCOVERY

KW - LIBRARIES

KW - PREDICTION

KW - DESIGN

KW - IDENTIFICATION

KW - CANDIDATES

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A crowdsourcing evaluation of the NIH chemical probes

Abstract

Keywords

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