A crowdsourcing evaluation of the NIH chemical probes

Tudor I. Oprea, Cristian G. Bologa, Scott Boyer, Ramona F. Curpan, Robert C. Glen, Andrew L. Hopkins, Christopher A. Lipinski, Garland R. Marshall, Yvonne C. Martin, Liliana Ostopovici-Halip, Gilbert Rishton, Oleg Ursu, Roy J. Vaz, Chris Waller, Herbert Waldmann, Larry A. Sklar

    Research output: Contribution to journalArticlepeer-review

    93 Citations (Scopus)

    Abstract

    Between 2004 and 2008, the US National Institutes of Health Molecular Libraries and Imaging initiative pilot phase funded 10 high-throughput screening centers, resulting in the deposition of 691 assays into PubChem and the nomination of 64 chemical probes. We crowdsourced the Molecular Libraries and Imaging initiative output to 11 experts, who expressed medium or high levels of confidence in 48 of these 64 probes.

    Original languageEnglish
    Pages (from-to)441-447
    Number of pages7
    JournalNature Chemical Biology
    Volume5
    Issue number7
    DOIs
    Publication statusPublished - Jul 2009

    Keywords

    • DRUG DISCOVERY
    • LEAD DISCOVERY
    • LIBRARIES
    • PREDICTION
    • DESIGN
    • IDENTIFICATION
    • CANDIDATES

    Cite this