A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing

Alastair Kerr, Bo Niklasson, Robert S. Dawe, Anne-Marie Escoffier, Maya Krasteva, Brian Sanderson, James Ferguson

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Background: The maximum concentration of organic sunscreen filters in current usage that does not lead to irritant reactions when performing photopatch testing is not known. Such irritant reactions can be misinterpreted as positive photoallergic contact dermatitis reactions.

    Objective: To determine the frequency of irritant reactions to 19 organic sunscreen filters in current use.

    Patients/Methods: Ninety-four healthy volunteers were photopatch tested using the European consensus methodology to three different concentrations (2%, 5%, and 10%) of 19 organic sunscreen filters at the Photobiology Unit in Dundee, UK.

    Results: Of the 94 subjects recruited, 80 were analysed after withdrawals and exclusions. Of the 19 organic sunscreen filters studied, only 2 compounds led to irritant reactions in >= 5% subjects. Five per cent and 10% benzophenone-4 led to irritant reactions in four and six subjects, respectively. Five per cent methylene bis-benzotriazolyl tetramethylbutylphenol led to irritant reactions in six subjects, but unlike benzophenone-4, this was not in a dose-dependent fashion.

    Conclusions: When performing photopatch testing according to the European consensus methodology with these 19 organic sunscreen filters, a 10% concentration is suitable for all filters, except benzophenone-4, which should be tested at a concentration of 2%.

    Original languageEnglish
    Pages (from-to)203-209
    Number of pages7
    JournalContact Dermatitis
    Volume60
    Issue number4
    Publication statusPublished - 2009

    Keywords

    • irritant reaction
    • organic sunscreen
    • photoallergic contact dermatitis
    • photopatch test
    • CONTACT-DERMATITIS
    • PATCH TEST
    • COSMETICS
    • SKIN

    Cite this

    Kerr, A., Niklasson, B., Dawe, R. S., Escoffier, A-M., Krasteva, M., Sanderson, B., & Ferguson, J. (2009). A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing. Contact Dermatitis, 60(4), 203-209.
    Kerr, Alastair ; Niklasson, Bo ; Dawe, Robert S. ; Escoffier, Anne-Marie ; Krasteva, Maya ; Sanderson, Brian ; Ferguson, James. / A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing. In: Contact Dermatitis. 2009 ; Vol. 60, No. 4. pp. 203-209.
    @article{39bb5b57a34548b1ae52d5533b8ba472,
    title = "A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing",
    abstract = "Background: The maximum concentration of organic sunscreen filters in current usage that does not lead to irritant reactions when performing photopatch testing is not known. Such irritant reactions can be misinterpreted as positive photoallergic contact dermatitis reactions.Objective: To determine the frequency of irritant reactions to 19 organic sunscreen filters in current use.Patients/Methods: Ninety-four healthy volunteers were photopatch tested using the European consensus methodology to three different concentrations (2{\%}, 5{\%}, and 10{\%}) of 19 organic sunscreen filters at the Photobiology Unit in Dundee, UK.Results: Of the 94 subjects recruited, 80 were analysed after withdrawals and exclusions. Of the 19 organic sunscreen filters studied, only 2 compounds led to irritant reactions in >= 5{\%} subjects. Five per cent and 10{\%} benzophenone-4 led to irritant reactions in four and six subjects, respectively. Five per cent methylene bis-benzotriazolyl tetramethylbutylphenol led to irritant reactions in six subjects, but unlike benzophenone-4, this was not in a dose-dependent fashion.Conclusions: When performing photopatch testing according to the European consensus methodology with these 19 organic sunscreen filters, a 10{\%} concentration is suitable for all filters, except benzophenone-4, which should be tested at a concentration of 2{\%}.",
    keywords = "irritant reaction, organic sunscreen, photoallergic contact dermatitis, photopatch test, CONTACT-DERMATITIS, PATCH TEST, COSMETICS, SKIN",
    author = "Alastair Kerr and Bo Niklasson and Dawe, {Robert S.} and Anne-Marie Escoffier and Maya Krasteva and Brian Sanderson and James Ferguson",
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    Kerr, A, Niklasson, B, Dawe, RS, Escoffier, A-M, Krasteva, M, Sanderson, B & Ferguson, J 2009, 'A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing', Contact Dermatitis, vol. 60, no. 4, pp. 203-209.

    A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing. / Kerr, Alastair; Niklasson, Bo; Dawe, Robert S.; Escoffier, Anne-Marie; Krasteva, Maya; Sanderson, Brian; Ferguson, James.

    In: Contact Dermatitis, Vol. 60, No. 4, 2009, p. 203-209.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing

    AU - Kerr, Alastair

    AU - Niklasson, Bo

    AU - Dawe, Robert S.

    AU - Escoffier, Anne-Marie

    AU - Krasteva, Maya

    AU - Sanderson, Brian

    AU - Ferguson, James

    PY - 2009

    Y1 - 2009

    N2 - Background: The maximum concentration of organic sunscreen filters in current usage that does not lead to irritant reactions when performing photopatch testing is not known. Such irritant reactions can be misinterpreted as positive photoallergic contact dermatitis reactions.Objective: To determine the frequency of irritant reactions to 19 organic sunscreen filters in current use.Patients/Methods: Ninety-four healthy volunteers were photopatch tested using the European consensus methodology to three different concentrations (2%, 5%, and 10%) of 19 organic sunscreen filters at the Photobiology Unit in Dundee, UK.Results: Of the 94 subjects recruited, 80 were analysed after withdrawals and exclusions. Of the 19 organic sunscreen filters studied, only 2 compounds led to irritant reactions in >= 5% subjects. Five per cent and 10% benzophenone-4 led to irritant reactions in four and six subjects, respectively. Five per cent methylene bis-benzotriazolyl tetramethylbutylphenol led to irritant reactions in six subjects, but unlike benzophenone-4, this was not in a dose-dependent fashion.Conclusions: When performing photopatch testing according to the European consensus methodology with these 19 organic sunscreen filters, a 10% concentration is suitable for all filters, except benzophenone-4, which should be tested at a concentration of 2%.

    AB - Background: The maximum concentration of organic sunscreen filters in current usage that does not lead to irritant reactions when performing photopatch testing is not known. Such irritant reactions can be misinterpreted as positive photoallergic contact dermatitis reactions.Objective: To determine the frequency of irritant reactions to 19 organic sunscreen filters in current use.Patients/Methods: Ninety-four healthy volunteers were photopatch tested using the European consensus methodology to three different concentrations (2%, 5%, and 10%) of 19 organic sunscreen filters at the Photobiology Unit in Dundee, UK.Results: Of the 94 subjects recruited, 80 were analysed after withdrawals and exclusions. Of the 19 organic sunscreen filters studied, only 2 compounds led to irritant reactions in >= 5% subjects. Five per cent and 10% benzophenone-4 led to irritant reactions in four and six subjects, respectively. Five per cent methylene bis-benzotriazolyl tetramethylbutylphenol led to irritant reactions in six subjects, but unlike benzophenone-4, this was not in a dose-dependent fashion.Conclusions: When performing photopatch testing according to the European consensus methodology with these 19 organic sunscreen filters, a 10% concentration is suitable for all filters, except benzophenone-4, which should be tested at a concentration of 2%.

    KW - irritant reaction

    KW - organic sunscreen

    KW - photoallergic contact dermatitis

    KW - photopatch test

    KW - CONTACT-DERMATITIS

    KW - PATCH TEST

    KW - COSMETICS

    KW - SKIN

    M3 - Article

    VL - 60

    SP - 203

    EP - 209

    JO - Contact Dermatitis

    JF - Contact Dermatitis

    SN - 0105-1873

    IS - 4

    ER -

    Kerr A, Niklasson B, Dawe RS, Escoffier A-M, Krasteva M, Sanderson B et al. A double-blind, randomized assessment of the irritant potential of sunscreen chemical dilutions used in photopatch testing. Contact Dermatitis. 2009;60(4):203-209.