A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

Fraser Stewart; Yangminghao Liu; Pierre Roncin; Ian P. Newton; Zhihong Huang; Inke Nathke; Sandy Cochran

doi:10.1109/ULTSYM.2017.8091959

A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

Fraser Stewart, Yangminghao Liu, Pierre Roncin, Ian P. Newton, Zhihong Huang, Inke Nathke, Sandy Cochran

Research output: Contribution to conference › Paper › peer-review

Abstract

Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

Original language	English
Number of pages	1
DOIs	https://doi.org/10.1109/ULTSYM.2017.8091959
Publication status	Published - 2 Nov 2017
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: 6 Sept 2017 → 9 Sept 2017

Conference

Conference	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country/Territory	United States
City	Washington
Period	6/09/17 → 9/09/17

Keywords

Transducers
Ultrasonic imaging
Targeted drug delivery
Biomedical optical imaging
Optical pumping
Optical sensors
Acoustics

ASJC Scopus subject areas

Acoustics and Ultrasonics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/ULTSYM.2017.8091959

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)
Cochran, S. (Investigator), Corner, G. (Investigator), Cuschieri, A. (Investigator), Nathke, I. (Investigator) & Steele, B. (Investigator)
Engineering and Physical Sciences Research Council
27/05/13 → 14/12/18
Project: Research

Cite this

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title = "A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery",

abstract = "Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.",

keywords = "Transducers, Ultrasonic imaging, Targeted drug delivery, Biomedical optical imaging, Optical pumping, Optical sensors, Acoustics",

author = "Fraser Stewart and Yangminghao Liu and Pierre Roncin and Newton, {Ian P.} and Zhihong Huang and Inke Nathke and Sandy Cochran",

year = "2017",

month = nov,

day = "2",

doi = "10.1109/ULTSYM.2017.8091959",

language = "English",

note = "2017 IEEE International Ultrasonics Symposium, IUS 2017 ; Conference date: 06-09-2017 Through 09-09-2017",

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T1 - A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

AU - Stewart, Fraser

AU - Liu, Yangminghao

AU - Roncin, Pierre

AU - Newton, Ian P.

AU - Huang, Zhihong

AU - Nathke, Inke

AU - Cochran, Sandy

PY - 2017/11/2

Y1 - 2017/11/2

N2 - Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

AB - Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

KW - Transducers

KW - Ultrasonic imaging

KW - Targeted drug delivery

KW - Biomedical optical imaging

KW - Optical pumping

KW - Optical sensors

KW - Acoustics

U2 - 10.1109/ULTSYM.2017.8091959

DO - 10.1109/ULTSYM.2017.8091959

M3 - Paper

AN - SCOPUS:85039460981

T2 - 2017 IEEE International Ultrasonics Symposium, IUS 2017

Y2 - 6 September 2017 through 9 September 2017

ER -

A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this