A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

Fraser Stewart, Yangminghao Liu, Pierre Roncin, Ian P. Newton, Zhihong Huang, Inke Nathke, Sandy Cochran

Research output: Contribution to conferencePaper

Abstract

Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

Original languageEnglish
Number of pages1
DOIs
Publication statusPublished - 2 Nov 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 6 Sep 20179 Sep 2017

Conference

Conference2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period6/09/179/09/17

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Keywords

  • Transducers
  • Ultrasonic imaging
  • Targeted drug delivery
  • Biomedical optical imaging
  • Optical pumping
  • Optical sensors
  • Acoustics

Cite this

Stewart, F., Liu, Y., Roncin, P., Newton, I. P., Huang, Z., Nathke, I., & Cochran, S. (2017). A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States. https://doi.org/10.1109/ULTSYM.2017.8091959