A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

Fraser Stewart, Yangminghao Liu, Pierre Roncin, Ian P. Newton, Zhihong Huang, Inke Nathke, Sandy Cochran

Research output: Contribution to conferencePaper

Abstract

Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

Original languageEnglish
Number of pages1
DOIs
Publication statusPublished - 2 Nov 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 6 Sep 20179 Sep 2017

Conference

Conference2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period6/09/179/09/17

Fingerprint

delivery
drugs
transducers
endoscopes
hyperthermia
capsules
cavitation flow
radiation

Keywords

  • Transducers
  • Ultrasonic imaging
  • Targeted drug delivery
  • Biomedical optical imaging
  • Optical pumping
  • Optical sensors
  • Acoustics

Cite this

Stewart, F., Liu, Y., Roncin, P., Newton, I. P., Huang, Z., Nathke, I., & Cochran, S. (2017). A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States. https://doi.org/10.1109/ULTSYM.2017.8091959
Stewart, Fraser ; Liu, Yangminghao ; Roncin, Pierre ; Newton, Ian P. ; Huang, Zhihong ; Nathke, Inke ; Cochran, Sandy. / A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States.1 p.
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abstract = "Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.",
keywords = "Transducers, Ultrasonic imaging, Targeted drug delivery, Biomedical optical imaging, Optical pumping, Optical sensors, Acoustics",
author = "Fraser Stewart and Yangminghao Liu and Pierre Roncin and Newton, {Ian P.} and Zhihong Huang and Inke Nathke and Sandy Cochran",
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Stewart, F, Liu, Y, Roncin, P, Newton, IP, Huang, Z, Nathke, I & Cochran, S 2017, 'A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery' Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 6/09/17 - 9/09/17, . https://doi.org/10.1109/ULTSYM.2017.8091959

A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery. / Stewart, Fraser; Liu, Yangminghao; Roncin, Pierre; Newton, Ian P.; Huang, Zhihong; Nathke, Inke; Cochran, Sandy.

2017. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States.

Research output: Contribution to conferencePaper

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T1 - A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery

AU - Stewart, Fraser

AU - Liu, Yangminghao

AU - Roncin, Pierre

AU - Newton, Ian P.

AU - Huang, Zhihong

AU - Nathke, Inke

AU - Cochran, Sandy

PY - 2017/11/2

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N2 - Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

AB - Focused ultrasound (US) produces clinically useful bioeffects such as hyperthermia, cavitation and radiation force. A focused US mediated targeted drug delivery (UmTDD) capsule endoscope was developed previously to explore treatment of gastrointestinal conditions such as Crohn's disease (SonoCAIT [1]). This included focused US transducers to enhance drug uptake into the bowel wall. In further development, a benchtop system was developed [2] using the same ultrasound sources. However, this system was limited and could only insonate single samples, required significant human intervention, and could only work on therapeutic agents in suspension rather than introduce them selectively. This paper describes the development of a fully automated system to overcome these issues and describes the development of application-specific focused US transducers.

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KW - Ultrasonic imaging

KW - Targeted drug delivery

KW - Biomedical optical imaging

KW - Optical pumping

KW - Optical sensors

KW - Acoustics

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Stewart F, Liu Y, Roncin P, Newton IP, Huang Z, Nathke I et al. A fully-automated insonation system for in vitro investigations of ultrasound-mediated targeted drug delivery. 2017. Paper presented at 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States. https://doi.org/10.1109/ULTSYM.2017.8091959