A genetic link between type 2 diabetes and prostate cancer

T. M. Frayling, H. Colhoun, J. C. Florez

    Research output: Contribution to journalComment/debate

    76 Citations (Scopus)

    Abstract

    Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

    Original languageEnglish
    Pages (from-to)1757-1760
    Number of pages4
    JournalDiabetologia
    Volume51
    Issue number10
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • Epidemiology
    • Genes
    • Genome-wide association study
    • Pleiotropy
    • Prostate cancer
    • Transcription factors
    • Type 2 diabetes
    • Genome-wide association
    • Metabolic syndrome
    • Reduced risk
    • US men
    • Variants
    • Mellitus
    • Mutations
    • Multiple
    • Loci
    • Susceptibility

    Cite this

    Frayling, T. M., Colhoun, H., & Florez, J. C. (2008). A genetic link between type 2 diabetes and prostate cancer. Diabetologia, 51(10), 1757-1760. https://doi.org/10.1007/s00125-008-1114-9