A genetic link between type 2 diabetes and prostate cancer

T. M. Frayling; H. Colhoun; J. C. Florez

doi:10.1007/s00125-008-1114-9

A genetic link between type 2 diabetes and prostate cancer

T. M. Frayling, H. Colhoun, J. C. Florez

Research output: Contribution to journal › Comment/debate › peer-review

82 Citations (Scopus)

Abstract

Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

Original language	English
Pages (from-to)	1757-1760
Number of pages	4
Journal	Diabetologia
Volume	51
Issue number	10
DOIs	https://doi.org/10.1007/s00125-008-1114-9
Publication status	Published - Oct 2008

Keywords

Epidemiology
Genes
Genome-wide association study
Pleiotropy
Prostate cancer
Transcription factors
Type 2 diabetes
Genome-wide association
Metabolic syndrome
Reduced risk
US men
Variants
Mellitus
Mutations
Multiple
Loci
Susceptibility

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00125-008-1114-9

Cite this

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title = "A genetic link between type 2 diabetes and prostate cancer",

abstract = "Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.",

keywords = "Epidemiology, Genes, Genome-wide association study, Pleiotropy, Prostate cancer, Transcription factors, Type 2 diabetes, Genome-wide association, Metabolic syndrome, Reduced risk, US men, Variants, Mellitus, Mutations, Multiple, Loci, Susceptibility",

author = "Frayling, {T. M.} and H. Colhoun and Florez, {J. C.}",

year = "2008",

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doi = "10.1007/s00125-008-1114-9",

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T1 - A genetic link between type 2 diabetes and prostate cancer

AU - Frayling, T. M.

AU - Colhoun, H.

AU - Florez, J. C.

PY - 2008/10

Y1 - 2008/10

N2 - Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

AB - Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

KW - Epidemiology

KW - Genes

KW - Genome-wide association study

KW - Pleiotropy

KW - Prostate cancer

KW - Transcription factors

KW - Type 2 diabetes

KW - Genome-wide association

KW - Metabolic syndrome

KW - Reduced risk

KW - US men

KW - Variants

KW - Mellitus

KW - Mutations

KW - Multiple

KW - Loci

KW - Susceptibility

U2 - 10.1007/s00125-008-1114-9

DO - 10.1007/s00125-008-1114-9

M3 - Comment/debate

C2 - 18696045

SN - 0012-186X

VL - 51

SP - 1757

EP - 1760

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

A genetic link between type 2 diabetes and prostate cancer

Abstract

Keywords

UN SDGs

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