A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer; Caitrin W McDonough; Pamela J Hicks; Bong H Roh; Maria R Wing; S Sandy An; Jessica M Hester; Jessica N Cooke; Meredith A Bostrom; Megan E Rudock; Matthew E Talbert; Joshua P Lewis; Assiamira Ferrara; Lingyi Lu; Julie T Ziegler; Michele M Sale; Jasmin Divers; Daniel Shriner; Adebowale Adeyemo; Charles N Rotimi; Maggie C Y Ng; Carl D Langefeld; Barry I Freedman; Donald W Bowden; DIAGRAM Consortium; MAGIC Investigators

doi:10.1371/journal.pone.0029202

A genome-wide association search for type 2 diabetes genes in African Americans

Nicholette D Palmer, Caitrin W McDonough, Pamela J Hicks, Bong H Roh, Maria R Wing, S Sandy An, Jessica M Hester, Jessica N Cooke, Meredith A Bostrom, Megan E Rudock, Matthew E Talbert, Joshua P Lewis, Assiamira Ferrara, Lingyi Lu, Julie T Ziegler, Michele M Sale, Jasmin Divers, Daniel Shriner, Adebowale Adeyemo, Charles N RotimiMaggie C Y Ng, Carl D Langefeld, Barry I Freedman, Donald W Bowden, DIAGRAM Consortium, MAGIC Investigators

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Abstract

African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n?=?550 independent loci) were genotyped in a replication cohort and 122 SNPs (n?=?98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P

Original language	English
Pages (from-to)	e29202
Journal	PLoS ONE
Volume	7
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0029202
Publication status	Published - 2012

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Palmer, N. D., McDonough, C. W., Hicks, P. J., Roh, B. H., Wing, M. R., An, S. S., Hester, J. M., Cooke, J. N., Bostrom, M. A., Rudock, M. E., Talbert, M. E., Lewis, J. P., Ferrara, A., Lu, L., Ziegler, J. T., Sale, M. M., Divers, J., Shriner, D., Adeyemo, A., ... MAGIC Investigators (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE, 7(1), e29202. https://doi.org/10.1371/journal.pone.0029202

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abstract = "African Americans are disproportionately affected by type 2 diabetes (T2DM) yet few studies have examined T2DM using genome-wide association approaches in this ethnicity. The aim of this study was to identify genes associated with T2DM in the African American population. We performed a Genome Wide Association Study (GWAS) using the Affymetrix 6.0 array in 965 African-American cases with T2DM and end-stage renal disease (T2DM-ESRD) and 1029 population-based controls. The most significant SNPs (n?=?550 independent loci) were genotyped in a replication cohort and 122 SNPs (n?=?98 independent loci) were further tested through genotyping three additional validation cohorts followed by meta-analysis in all five cohorts totaling 3,132 cases and 3,317 controls. Twelve SNPs had evidence of association in the GWAS (P",

author = "Palmer, {Nicholette D} and McDonough, {Caitrin W} and Hicks, {Pamela J} and Roh, {Bong H} and Wing, {Maria R} and An, {S Sandy} and Hester, {Jessica M} and Cooke, {Jessica N} and Bostrom, {Meredith A} and Rudock, {Megan E} and Talbert, {Matthew E} and Lewis, {Joshua P} and Assiamira Ferrara and Lingyi Lu and Ziegler, {Julie T} and Sale, {Michele M} and Jasmin Divers and Daniel Shriner and Adebowale Adeyemo and Rotimi, {Charles N} and Ng, {Maggie C Y} and Langefeld, {Carl D} and Freedman, {Barry I} and Bowden, {Donald W} and Voight, {Benjamin F} and Scott, {Laura J} and Valgerdur Steinthorsdottir and Morris, {Andrew P} and Christian Dina and Welch, {Ryan P} and Eleftheria Zeggini and Cornelia Huth and Aulchenko, {Yurii S} and Gudmar Thorleifsson and McCulloch, {Laura J} and Teresa Ferreira and Harald Grallert and Najaf Amin and Guanming Wu and Willer, {Cristen J} and Soumya Raychaudhuri and McCarroll, {Steve A} and Claudia Langenberg and Hofmann, {Oliver M} and Jos{\'e}e Dupuis and Lu Qi and Segr{\`e}, {Ayellet V} and Doney, {Alexander S. F.} and Morris, {Andrew D} and Palmer, {Colin N A} and {DIAGRAM Consortium} and {MAGIC Investigators}",

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Palmer, ND, McDonough, CW, Hicks, PJ, Roh, BH, Wing, MR, An, SS, Hester, JM, Cooke, JN, Bostrom, MA, Rudock, ME, Talbert, ME, Lewis, JP, Ferrara, A, Lu, L, Ziegler, JT, Sale, MM, Divers, J, Shriner, D, Adeyemo, A, Rotimi, CN, Ng, MCY, Langefeld, CD, Freedman, BI, Bowden, DW, DIAGRAM Consortium & MAGIC Investigators 2012, 'A genome-wide association search for type 2 diabetes genes in African Americans', PLoS ONE, vol. 7, no. 1, pp. e29202. https://doi.org/10.1371/journal.pone.0029202

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AU - Palmer, Nicholette D

AU - McDonough, Caitrin W

AU - Hicks, Pamela J

AU - Roh, Bong H

AU - Wing, Maria R

AU - An, S Sandy

AU - Hester, Jessica M

AU - Cooke, Jessica N

AU - Bostrom, Meredith A

AU - Rudock, Megan E

AU - Talbert, Matthew E

AU - Lewis, Joshua P

AU - Ferrara, Assiamira

AU - Lu, Lingyi

AU - Ziegler, Julie T

AU - Sale, Michele M

AU - Divers, Jasmin

AU - Shriner, Daniel

AU - Adeyemo, Adebowale

AU - Rotimi, Charles N

AU - Ng, Maggie C Y

AU - Langefeld, Carl D

AU - Freedman, Barry I

AU - Bowden, Donald W

AU - Voight, Benjamin F

AU - Scott, Laura J

AU - Steinthorsdottir, Valgerdur

AU - Morris, Andrew P

AU - Dina, Christian

AU - Welch, Ryan P

AU - Zeggini, Eleftheria

AU - Huth, Cornelia

AU - Aulchenko, Yurii S

AU - Thorleifsson, Gudmar

AU - McCulloch, Laura J

AU - Ferreira, Teresa

AU - Grallert, Harald

AU - Amin, Najaf

AU - Wu, Guanming

AU - Willer, Cristen J

AU - Raychaudhuri, Soumya

AU - McCarroll, Steve A

AU - Langenberg, Claudia

AU - Hofmann, Oliver M

AU - Dupuis, Josée

AU - Qi, Lu

AU - Segrè, Ayellet V

AU - Doney, Alexander S. F.

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AU - DIAGRAM Consortium

AU - MAGIC Investigators

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DO - 10.1371/journal.pone.0029202

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VL - 7

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JO - PLoS ONE

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A genome-wide association search for type 2 diabetes genes in African Americans

Abstract

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