A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

Weihua Meng; Abirami Veluchamy; Harry Hebert; Amy Campbell; Helen M. Colhoun; Colin Palmer

doi:10.1111/bjd.15787

A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

Weihua Meng (Lead / Corresponding author), Abirami Veluchamy, Harry Hebert, Amy Campbell, Helen M. Colhoun, Colin Palmer

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.

Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.

Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.

Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.

Conclusions: We suggest that the MAPK14 gene is associated with DFU.

Original language	English
Pages (from-to)	1664-1670
Number of pages	7
Journal	British Journal of Dermatology
Volume	177
Issue number	6
Early online date	3 Jul 2017
DOIs	https://doi.org/10.1111/bjd.15787
Publication status	Published - Dec 2017

Keywords

genetics
genome-wide association study
diabetes
diabetic foot ulcer
MAPK14
MAPK pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bjd.15787Licence: CC BY

Final Published VersionFinal published version, 408 KBLicence: CC BY

Meng, Weihua
- Population Health and Genomics - Honorary Senior Lecturer
Person: Honorary

Cite this

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title = "A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer",

abstract = "Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.Conclusions: We suggest that the MAPK14 gene is associated with DFU.",

keywords = "genetics, genome-wide association study, diabetes, diabetic foot ulcer, MAPK14, MAPK pathway",

author = "Weihua Meng and Abirami Veluchamy and Harry Hebert and Amy Campbell and Colhoun, {Helen M.} and Colin Palmer",

note = "Funding statement: This study is funded by a Tenovus grant (2015-T15/40). The GoDARTS project was jointly funded by DIABETES UK and The Wellcome Trust.",

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A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer. / Meng, Weihua (Lead / Corresponding author); Veluchamy, Abirami ; Hebert, Harry et al.
In: British Journal of Dermatology, Vol. 177, No. 6, 12.2017, p. 1664-1670.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

AU - Meng, Weihua

AU - Veluchamy, Abirami

AU - Hebert, Harry

AU - Campbell, Amy

AU - Colhoun, Helen M.

AU - Palmer, Colin

N1 - Funding statement: This study is funded by a Tenovus grant (2015-T15/40). The GoDARTS project was jointly funded by DIABETES UK and The Wellcome Trust.

PY - 2017/12

Y1 - 2017/12

N2 - Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.Conclusions: We suggest that the MAPK14 gene is associated with DFU.

AB - Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.Conclusions: We suggest that the MAPK14 gene is associated with DFU.

KW - genetics

KW - genome-wide association study

KW - diabetes

KW - diabetic foot ulcer

KW - MAPK14

KW - MAPK pathway

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DO - 10.1111/bjd.15787

M3 - Article

C2 - 28672053

SN - 0007-0963

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SP - 1664

EP - 1670

JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 6

ER -

A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

Abstract

Keywords

UN SDGs

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Meng, Weihua

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