A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

Weihua Meng (Lead / Corresponding author), Abirami Veluchamy, Harry Hebert, Amy Campbell, Helen M. Colhoun, Colin Palmer

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3 Citations (Scopus)
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Abstract

Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.

Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.

Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.

Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.

Conclusions: We suggest that the MAPK14 gene is associated with DFU.
Original languageEnglish
Pages (from-to)1664-1670
Number of pages7
JournalBritish Journal of Dermatology
Volume177
Issue number6
Early online date3 Jul 2017
DOIs
Publication statusPublished - Dec 2017

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Mitogen-Activated Protein Kinase 14
Diabetic Foot
Genome-Wide Association Study
Foot Ulcer
Health
Genes
Foot
Scotland
Diabetes Complications
Genome
Phenotype
Research

Keywords

  • genetics
  • genome-wide association study
  • diabetes
  • diabetic foot ulcer
  • MAPK14
  • MAPK pathway

Cite this

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title = "A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer",
abstract = "Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.Conclusions: We suggest that the MAPK14 gene is associated with DFU.",
keywords = "genetics, genome-wide association study, diabetes, diabetic foot ulcer, MAPK14, MAPK pathway",
author = "Weihua Meng and Abirami Veluchamy and Harry Hebert and Amy Campbell and Colhoun, {Helen M.} and Colin Palmer",
note = "Funding statement: This study is funded by a Tenovus grant (2015-T15/40). The GoDARTS project was jointly funded by DIABETES UK and The Wellcome Trust.",
year = "2017",
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T1 - A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

AU - Meng, Weihua

AU - Veluchamy, Abirami

AU - Hebert, Harry

AU - Campbell, Amy

AU - Colhoun, Helen M.

AU - Palmer, Colin

N1 - Funding statement: This study is funded by a Tenovus grant (2015-T15/40). The GoDARTS project was jointly funded by DIABETES UK and The Wellcome Trust.

PY - 2017/12

Y1 - 2017/12

N2 - Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.Conclusions: We suggest that the MAPK14 gene is associated with DFU.

AB - Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.Conclusions: We suggest that the MAPK14 gene is associated with DFU.

KW - genetics

KW - genome-wide association study

KW - diabetes

KW - diabetic foot ulcer

KW - MAPK14

KW - MAPK pathway

U2 - 10.1111/bjd.15787

DO - 10.1111/bjd.15787

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