A genome-wide association study suggested that the mitogen-activated protein kinase 14 gene (MAPK14) is associated with diabetic foot ulcer

Weihua Meng (Lead / Corresponding author), Abirami Veluchamy, Harry Hebert, Amy Campbell, Helen M. Colhoun, Colin Palmer

Research output: Contribution to journalArticle

8 Citations (Scopus)
116 Downloads (Pure)

Abstract

Background: Diabetic foot ulcer (DFU) is a devastating complication of diabetes.

Objectives: We aimed to identify genetic contributors of DFU based on a genome-wide association study approach using a Scottish diabetic cohort.

Methods: A genome-wide association approach was applied. A case was defined as a diabetic patient (type 1 or type 2) who had ever been recorded in the linked e-health records as having a foot ulcer (current or previous) in at least one foot as well as a positive result of the monofilament test in the longitudinal e-health records. A control in this study was defined as a diabetic individual (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot in the linked e-health records and the monofilament test results of any foot was once recorded to be positive in the longitudinal e-health records.

Results: We have 699 DFU cases and 2,695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The lowest P value of rs80028505 (Chr6p21.31) in the MAPK14 gene was 2.45x10-8. The narrow-sense heritability of this phenotype is 0.06.

Conclusions: We suggest that the MAPK14 gene is associated with DFU.
Original languageEnglish
Pages (from-to)1664-1670
Number of pages7
JournalBritish Journal of Dermatology
Volume177
Issue number6
Early online date3 Jul 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • genetics
  • genome-wide association study
  • diabetes
  • diabetic foot ulcer
  • MAPK14
  • MAPK pathway

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