A Good Day for Helminths: how parasite-derived GDH suppresses inflammatory responses

Suzanne H. Hodge; Henry J. McSorley

doi:10.15252/embr.202255054

A Good Day for Helminths: how parasite-derived GDH suppresses inflammatory responses

Suzanne H. Hodge, Henry J. McSorley (Lead / Corresponding author)

Cell Signalling and Immunology

Research output: Contribution to journal › Comment/debate › peer-review

2 Citations (Scopus)

106 Downloads (Pure)

Abstract

Parasitic helminths are often associated with immunoregulation, which allows them to survive in their hosts in the face of type 2 immune responses. They achieve this feat through the secretion of multiple immunomodulatory factors. In this issue of EMBO Reports, Prodjinotho et al show that the parasitic cestode Taenia solium induces regulatory T-cell responses in mice and humans through the release of the metabolic enzyme Glutamate dehydrogenase (GDH), which may be a conserved pathway of immunoregulation in many helminths (Prodjinotho et al, 2022).

Original language	English
Article number	e55054
Number of pages	3
Journal	EMBO Reports
Volume	23
Issue number	5
Early online date	31 Mar 2022
DOIs	https://doi.org/10.15252/embr.202255054
Publication status	Published - 4 May 2022

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10.15252/embr.202255054Licence: CC BY-NC-ND

Final Published VersionFinal published version, 452 KBLicence: CC BY-NC-ND

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title = "A Good Day for Helminths: how parasite-derived GDH suppresses inflammatory responses",

abstract = "Parasitic helminths are often associated with immunoregulation, which allows them to survive in their hosts in the face of type 2 immune responses. They achieve this feat through the secretion of multiple immunomodulatory factors. In this issue of EMBO Reports, Prodjinotho et al show that the parasitic cestode Taenia solium induces regulatory T-cell responses in mice and humans through the release of the metabolic enzyme Glutamate dehydrogenase (GDH), which may be a conserved pathway of immunoregulation in many helminths (Prodjinotho et al, 2022).",

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AU - McSorley, Henry J.

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AB - Parasitic helminths are often associated with immunoregulation, which allows them to survive in their hosts in the face of type 2 immune responses. They achieve this feat through the secretion of multiple immunomodulatory factors. In this issue of EMBO Reports, Prodjinotho et al show that the parasitic cestode Taenia solium induces regulatory T-cell responses in mice and humans through the release of the metabolic enzyme Glutamate dehydrogenase (GDH), which may be a conserved pathway of immunoregulation in many helminths (Prodjinotho et al, 2022).

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A Good Day for Helminths: how parasite-derived GDH suppresses inflammatory responses

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