A Good Day for Helminths: how parasite-derived GDH suppresses inflammatory responses

Suzanne H. Hodge, Henry J. McSorley (Lead / Corresponding author)

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)
28 Downloads (Pure)

Abstract

Parasitic helminths are often associated with immunoregulation, which allows them to survive in their hosts in the face of type 2 immune responses. They achieve this feat through the secretion of multiple immunomodulatory factors. In this issue of EMBO Reports, Prodjinotho et al show that the parasitic cestode Taenia solium induces regulatory T-cell responses in mice and humans through the release of the metabolic enzyme Glutamate dehydrogenase (GDH), which may be a conserved pathway of immunoregulation in many helminths (Prodjinotho et al, 2022).

Original languageEnglish
Article numbere55054
Number of pages3
JournalEMBO Reports
Volume23
Issue number5
Early online date31 Mar 2022
DOIs
Publication statusPublished - 4 May 2022

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