A harmless high?

TY - JOUR

T1 - A harmless high?

AU - Sammler, Esther M

AU - Foley, Peter L

AU - Lauder, Gavin D

AU - Wilson, Simon J

AU - Goudie, Andrew R

AU - O'Riordan, Jonathan I

PY - 2010/8/28

Y1 - 2010/8/28

N2 - In March, 2010, a 15-year-old girl presented to our accident and emergency department with altered mental status, nausea, and vomiting. During the previous evening she had been out with friends, and had consumed a white powdery substance together with alcohol. On the day of admission she had become increasingly unwell, with symptoms that could not be attributed to a hangover and presented to us in the afternoon. Upon arrival, our patient was somnolent with a Glasgow Coma Score of 11 she opened her eyes in response to speech, uttered inappropriate words, and localised to pain. Blood pressure was 108/58 mm Hg; pulse rate was 54 beats per min; respiratory rate was 15 breaths per min; and ear-temperature was 36°C. Arterial blood gas analysis and 12-lead electrocardiogram were normal. There was no evidence of external injury, neck stiffness, or localising neurological signs. Her pupils were dilated but reactive to light; there was no papilloedema. The remainder of the physical examination was normal.

AB - In March, 2010, a 15-year-old girl presented to our accident and emergency department with altered mental status, nausea, and vomiting. During the previous evening she had been out with friends, and had consumed a white powdery substance together with alcohol. On the day of admission she had become increasingly unwell, with symptoms that could not be attributed to a hangover and presented to us in the afternoon. Upon arrival, our patient was somnolent with a Glasgow Coma Score of 11 she opened her eyes in response to speech, uttered inappropriate words, and localised to pain. Blood pressure was 108/58 mm Hg; pulse rate was 54 beats per min; respiratory rate was 15 breaths per min; and ear-temperature was 36°C. Arterial blood gas analysis and 12-lead electrocardiogram were normal. There was no evidence of external injury, neck stiffness, or localising neurological signs. Her pupils were dilated but reactive to light; there was no papilloedema. The remainder of the physical examination was normal.

KW - Adolescent

KW - Central Nervous System Stimulants/poisoning

KW - Designer Drugs/poisoning

KW - Female

KW - Humans

KW - Methamphetamine/analogs & derivatives

KW - Neurotoxicity Syndromes/diagnosis

U2 - 10.1016/S0140-6736(10)60891-4

DO - 10.1016/S0140-6736(10)60891-4

M3 - Article

C2 - 20801405

SN - 0140-6736

VL - 376

JO - Lancet

JF - Lancet

IS - 9742

M1 - 742

ER -