A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women: findings from the Aberdeen Prospective Osteoporosis Screening Study

Andrew D. Ablett, Adrian D. Wood, Rebecca Barr, Jordan Guillot, Alison J. Black, Helen M. Macdonald, David M. Reid, Phyo K. Myint

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9 Citations (Scopus)
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Abstract

Purpose: To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study. Methods: ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997–2000). Outcomes were examined using logistic regression. Model adjustments were selected a priori based on expert opinion. Results: Of 3883 participants, 3293 scored ACB = 0, 328 scored ACB = 1, and 262 scored ACB ≥2. High ACB burden (≥2) was associated with increased odds (ACB = 0 reference) for falls (fully adjusted odds ratio [95% confidence intervals] = 1.81 [1.25–2.62]; P = 0.002) and having low bone mineral density (lowest quintile-20%) at Ward's triangle (3.22 [1.30–7.99]; P = 0.01). A history of falls over the year prior to the study visit in participants with ACB score ≥2 was 32 per 100. For ACB categories 1 and 0, a history of falls per 100 was 21 and 22, respectively. Conclusions: The risk of falling associated with ACB observed in older age may also extend to middle-aged women.

Original languageEnglish
Pages (from-to)557-562
Number of pages8
JournalAnnals of Epidemiology
Volume28
Issue number8
Early online date2 Jun 2018
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Anti-cholinergic
  • Bone mineral density
  • Epidemiology
  • Falls
  • Fracture
  • Middle age
  • Women

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