A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women: findings from the Aberdeen Prospective Osteoporosis Screening Study

TY - JOUR

T1 - A high anticholinergic burden is associated with a history of falls in the previous year in middle-aged women

T2 - findings from the Aberdeen Prospective Osteoporosis Screening Study

AU - Ablett, Andrew D.

AU - Wood, Adrian D.

AU - Barr, Rebecca

AU - Guillot, Jordan

AU - Black, Alison J.

AU - Macdonald, Helen M.

AU - Reid, David M.

AU - Myint, Phyo K.

PY - 2018/8

Y1 - 2018/8

N2 - Purpose: To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study. Methods: ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997–2000). Outcomes were examined using logistic regression. Model adjustments were selected a priori based on expert opinion. Results: Of 3883 participants, 3293 scored ACB = 0, 328 scored ACB = 1, and 262 scored ACB ≥2. High ACB burden (≥2) was associated with increased odds (ACB = 0 reference) for falls (fully adjusted odds ratio [95% confidence intervals] = 1.81 [1.25–2.62]; P = 0.002) and having low bone mineral density (lowest quintile-20%) at Ward's triangle (3.22 [1.30–7.99]; P = 0.01). A history of falls over the year prior to the study visit in participants with ACB score ≥2 was 32 per 100. For ACB categories 1 and 0, a history of falls per 100 was 21 and 22, respectively. Conclusions: The risk of falling associated with ACB observed in older age may also extend to middle-aged women.

AB - Purpose: To examine the cross-sectional association between anticholinergic medication burden (ACB) and a history of falls, bone mineral density, and low trauma fractures in middle-aged women aged under 65 years from the Aberdeen Prospective Osteoporosis Screening Study. Methods: ACB (0 = none, 1 = possible, ≥2 = definite) was calculated from medication use for 3883 Caucasian women [mean age (SD) = 54.3 (2.3) years] attending the second Aberdeen Prospective Osteoporosis Screening Study visit (1997–2000). Outcomes were examined using logistic regression. Model adjustments were selected a priori based on expert opinion. Results: Of 3883 participants, 3293 scored ACB = 0, 328 scored ACB = 1, and 262 scored ACB ≥2. High ACB burden (≥2) was associated with increased odds (ACB = 0 reference) for falls (fully adjusted odds ratio [95% confidence intervals] = 1.81 [1.25–2.62]; P = 0.002) and having low bone mineral density (lowest quintile-20%) at Ward's triangle (3.22 [1.30–7.99]; P = 0.01). A history of falls over the year prior to the study visit in participants with ACB score ≥2 was 32 per 100. For ACB categories 1 and 0, a history of falls per 100 was 21 and 22, respectively. Conclusions: The risk of falling associated with ACB observed in older age may also extend to middle-aged women.

KW - Anti-cholinergic

KW - Bone mineral density

KW - Epidemiology

KW - Falls

KW - Fracture

KW - Middle age

KW - Women

U2 - 10.1016/j.annepidem.2018.05.011

DO - 10.1016/j.annepidem.2018.05.011

M3 - Article

C2 - 29937404

AN - SCOPUS:85048818595

SN - 1047-2797

VL - 28

SP - 557

EP - 562

JO - Annals of Epidemiology

JF - Annals of Epidemiology

IS - 8

ER -