A high macrophage content in human breast cancer is not associated with favourable prognostic factors

R. J. C. Steele, O. Eremin, M. Brown, R. A. Hawkins

    Research output: Contribution to journalArticle

    26 Citations (Scopus)

    Abstract

    The macrophage contents of 40 human primary breast cancers were ascertained using three separate macrophage membrane markers. Four prognostic factors (lymph node status, tumour size, histological grade and oestrogen receptor status) were determined concurrently in these mammary carcinomas. No significant relationship was found between the macrophage content of the mammary carcinomas and any individual prognostic factor. When the patients were grouped according to whether they had 0-2 or 3-4 high risk factors, however, the macrophage content was significantly greater in those tumours with the poorer prognosis, regardless of the marker used to enumerate the cells. A high macrophage content, therefore, is not associated with favourable prognostic factors in breast cancer. Indeed, the present study has revealed the reverse to be the case.
    Original languageEnglish
    Pages (from-to)456-8
    Number of pages3
    JournalBritish Journal of Surgery
    Volume71
    Issue number6
    DOIs
    Publication statusPublished - Jun 1984

    Keywords

    • Axilla
    • Breast Neoplasms
    • Cell Count
    • Female
    • Humans
    • Lymph Nodes
    • Macrophages
    • Prognosis
    • Receptors, Estrogen

    Fingerprint Dive into the research topics of 'A high macrophage content in human breast cancer is not associated with favourable prognostic factors'. Together they form a unique fingerprint.

  • Cite this