A high macrophage content in human breast cancer is not associated with favourable prognostic factors

R. J. C. Steele, O. Eremin, M. Brown, R. A. Hawkins

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    Abstract

    The macrophage contents of 40 human primary breast cancers were ascertained using three separate macrophage membrane markers. Four prognostic factors (lymph node status, tumour size, histological grade and oestrogen receptor status) were determined concurrently in these mammary carcinomas. No significant relationship was found between the macrophage content of the mammary carcinomas and any individual prognostic factor. When the patients were grouped according to whether they had 0-2 or 3-4 high risk factors, however, the macrophage content was significantly greater in those tumours with the poorer prognosis, regardless of the marker used to enumerate the cells. A high macrophage content, therefore, is not associated with favourable prognostic factors in breast cancer. Indeed, the present study has revealed the reverse to be the case.
    Original languageEnglish
    Pages (from-to)456-8
    Number of pages3
    JournalBritish Journal of Surgery
    Volume71
    Issue number6
    DOIs
    Publication statusPublished - Jun 1984

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    Macrophages
    Breast Neoplasms
    Estrogen Receptors
    Neoplasms
    Lymph Nodes
    Membranes

    Keywords

    • Axilla
    • Breast Neoplasms
    • Cell Count
    • Female
    • Humans
    • Lymph Nodes
    • Macrophages
    • Prognosis
    • Receptors, Estrogen

    Cite this

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    abstract = "The macrophage contents of 40 human primary breast cancers were ascertained using three separate macrophage membrane markers. Four prognostic factors (lymph node status, tumour size, histological grade and oestrogen receptor status) were determined concurrently in these mammary carcinomas. No significant relationship was found between the macrophage content of the mammary carcinomas and any individual prognostic factor. When the patients were grouped according to whether they had 0-2 or 3-4 high risk factors, however, the macrophage content was significantly greater in those tumours with the poorer prognosis, regardless of the marker used to enumerate the cells. A high macrophage content, therefore, is not associated with favourable prognostic factors in breast cancer. Indeed, the present study has revealed the reverse to be the case.",
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    A high macrophage content in human breast cancer is not associated with favourable prognostic factors. / Steele, R. J. C.; Eremin, O.; Brown, M.; Hawkins, R. A.

    In: British Journal of Surgery, Vol. 71, No. 6, 06.1984, p. 456-8.

    Research output: Contribution to journalArticle

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    T1 - A high macrophage content in human breast cancer is not associated with favourable prognostic factors

    AU - Steele, R. J. C.

    AU - Eremin, O.

    AU - Brown, M.

    AU - Hawkins, R. A.

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    AB - The macrophage contents of 40 human primary breast cancers were ascertained using three separate macrophage membrane markers. Four prognostic factors (lymph node status, tumour size, histological grade and oestrogen receptor status) were determined concurrently in these mammary carcinomas. No significant relationship was found between the macrophage content of the mammary carcinomas and any individual prognostic factor. When the patients were grouped according to whether they had 0-2 or 3-4 high risk factors, however, the macrophage content was significantly greater in those tumours with the poorer prognosis, regardless of the marker used to enumerate the cells. A high macrophage content, therefore, is not associated with favourable prognostic factors in breast cancer. Indeed, the present study has revealed the reverse to be the case.

    KW - Axilla

    KW - Breast Neoplasms

    KW - Cell Count

    KW - Female

    KW - Humans

    KW - Lymph Nodes

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    KW - Prognosis

    KW - Receptors, Estrogen

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