A key role for the GINS complex at DNA replication forks

Karim Labib, Agnieszka Gambus

    Research output: Contribution to journalReview articlepeer-review

    94 Citations (Scopus)

    Abstract

    The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.

    Original languageEnglish
    Pages (from-to)271-278
    Number of pages8
    JournalTrends in Cell Biology
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - Jun 2007

    Keywords

    • POLYMERASE ALPHA-PRIMASE
    • CDC45
    • MCM COMPLEX
    • S-PHASE PROGRESSION
    • BUDDING YEAST
    • EUKARYOTIC DNA
    • SACCHAROMYCES-CEREVISIAE
    • CDK-DEPENDENT PHOSPHORYLATION
    • SLD3
    • XENOPUS EGG EXTRACTS

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