A key role for the GINS complex at DNA replication forks

Karim Labib; Agnieszka Gambus

doi:10.1016/j.tcb.2007.04.002

A key role for the GINS complex at DNA replication forks

Karim Labib, Agnieszka Gambus

Research output: Contribution to journal › Review article › peer-review

110 Citations (Scopus)

Abstract

The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.

Original language	English
Pages (from-to)	271-278
Number of pages	8
Journal	Trends in Cell Biology
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.tcb.2007.04.002
Publication status	Published - Jun 2007

Keywords

POLYMERASE ALPHA-PRIMASE
CDC45
MCM COMPLEX
S-PHASE PROGRESSION
BUDDING YEAST
EUKARYOTIC DNA
SACCHAROMYCES-CEREVISIAE
CDK-DEPENDENT PHOSPHORYLATION
SLD3
XENOPUS EGG EXTRACTS

Access to Document

10.1016/j.tcb.2007.04.002

Cite this

@article{967f66bf7f434208a4d802ef120fb5cd,

title = "A key role for the GINS complex at DNA replication forks",

abstract = "The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.",

keywords = "POLYMERASE ALPHA-PRIMASE, CDC45, MCM COMPLEX, S-PHASE PROGRESSION, BUDDING YEAST, EUKARYOTIC DNA, SACCHAROMYCES-CEREVISIAE, CDK-DEPENDENT PHOSPHORYLATION, SLD3, XENOPUS EGG EXTRACTS",

author = "Karim Labib and Agnieszka Gambus",

year = "2007",

month = jun,

doi = "10.1016/j.tcb.2007.04.002",

language = "English",

volume = "17",

pages = "271--278",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - A key role for the GINS complex at DNA replication forks

AU - Labib, Karim

AU - Gambus, Agnieszka

PY - 2007/6

Y1 - 2007/6

N2 - The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.

AB - The GINS complex is the most recently identified component of the eukaryotic DNA replication machinery and is required both for the initiation of chromosome replication and also for the normal progression of DNA replication forks. Several recent studies suggest that GINS associates at replication forks with the MCM helicase that is responsible for unwinding the parental DNA duplex. Archaea also have an equivalent GINS complex that can interact with MCM and other replisome components. It seems likely that GINS couples MCM to other key proteins at forks, and we discuss here the current literature regarding this important late-comer to the DNA replication field.

KW - POLYMERASE ALPHA-PRIMASE

KW - CDC45

KW - MCM COMPLEX

KW - S-PHASE PROGRESSION

KW - BUDDING YEAST

KW - EUKARYOTIC DNA

KW - SACCHAROMYCES-CEREVISIAE

KW - CDK-DEPENDENT PHOSPHORYLATION

KW - SLD3

KW - XENOPUS EGG EXTRACTS

U2 - 10.1016/j.tcb.2007.04.002

DO - 10.1016/j.tcb.2007.04.002

M3 - Review article

C2 - 17467990

SN - 0962-8924

VL - 17

SP - 271

EP - 278

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 6

ER -

A key role for the GINS complex at DNA replication forks

Abstract

Keywords

Access to Document

Fingerprint

Cite this