A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

Giulia Vallardi, Marilia Henriques Cordeiro, Adrian Thomas Saurin (Lead / Corresponding author)

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

    12 Citations (Scopus)
    281 Downloads (Pure)


    The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.

    Original languageEnglish
    Title of host publicationCentromeres and Kinetochores
    Subtitle of host publicationDiscovering the Molecular Mechanisms Underlying Chromosome Inheritance
    EditorsBen E. Black
    Place of PublicationSwitzerland
    PublisherSpringer International Publishing
    Number of pages28
    ISBN (Electronic) 9783319585925
    ISBN (Print)9783319585918
    Publication statusPublished - 2017

    Publication series

    NameProgress in Molecular and Subcellular Biology
    PublisherSpringer International Publishing


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