A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

Giulia Vallardi; Marilia Henriques Cordeiro; Adrian Thomas Saurin

doi:10.1007/978-3-319-58592-5_19

A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

Giulia Vallardi, Marilia Henriques Cordeiro, Adrian Thomas Saurin (Lead / Corresponding author)

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

12 Citations (Scopus)

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Abstract

The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.

Original language	English
Title of host publication	Centromeres and Kinetochores
Subtitle of host publication	Discovering the Molecular Mechanisms Underlying Chromosome Inheritance
Editors	Ben E. Black
Place of Publication	Switzerland
Publisher	Springer International Publishing
Pages	457-484
Number of pages	28
Volume	56
ISBN (Electronic)	9783319585925
ISBN (Print)	9783319585918
DOIs	https://doi.org/10.1007/978-3-319-58592-5_19
Publication status	Published - 2017

Publication series

Name	Progress in Molecular and Subcellular Biology
Publisher	Springer International Publishing
Volume	56

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10.1007/978-3-319-58592-5_19

Author Accepted Manuscript
The final publication is available at springer.com via http://dx.doi.org/10.1007/978-3-319-58592-5_19.
Accepted author manuscript, 4.68 MB

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Vallardi, G., Cordeiro, M. H., & Saurin, A. T. (2017). A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. In B. E. Black (Ed.), Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance (Vol. 56, pp. 457-484). (Progress in Molecular and Subcellular Biology; Vol. 56). Springer International Publishing. https://doi.org/10.1007/978-3-319-58592-5_19

Vallardi, Giulia ; Cordeiro, Marilia Henriques ; Saurin, Adrian Thomas. / A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. editor / Ben E. Black. Vol. 56 Switzerland : Springer International Publishing, 2017. pp. 457-484 (Progress in Molecular and Subcellular Biology).

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abstract = "The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.",

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Vallardi, G, Cordeiro, MH & Saurin, AT 2017, A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. in BE Black (ed.), Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. vol. 56, Progress in Molecular and Subcellular Biology, vol. 56, Springer International Publishing, Switzerland, pp. 457-484. https://doi.org/10.1007/978-3-319-58592-5_19

A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. / Vallardi, Giulia; Cordeiro, Marilia Henriques; Saurin, Adrian Thomas (Lead / Corresponding author).
Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. ed. / Ben E. Black. Vol. 56 Switzerland: Springer International Publishing, 2017. p. 457-484 (Progress in Molecular and Subcellular Biology; Vol. 56).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

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T1 - A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

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AB - The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.

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DO - 10.1007/978-3-319-58592-5_19

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Vallardi G, Cordeiro MH, Saurin AT. A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. In Black BE, editor, Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. Vol. 56. Switzerland: Springer International Publishing. 2017. p. 457-484. (Progress in Molecular and Subcellular Biology). Epub 2017 Aug 25. doi: 10.1007/978-3-319-58592-5_19

A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

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