A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    3 Citations (Scopus)
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    Abstract

    The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.

    Original languageEnglish
    Title of host publicationCentromeres and Kinetochores
    Subtitle of host publicationDiscovering the Molecular Mechanisms Underlying Chromosome Inheritance
    EditorsBen E. Black
    Place of PublicationSwitzerland
    PublisherSpringer International Publishing
    Pages457-484
    Number of pages28
    Volume56
    ISBN (Electronic) 9783319585925
    ISBN (Print)9783319585918
    DOIs
    Publication statusPublished - 2017

    Publication series

    NameProgress in Molecular and Subcellular Biology
    PublisherSpringer International Publishing
    Volume56

    Fingerprint

    M Phase Cell Cycle Checkpoints
    Kinetochores
    Phosphoric Monoester Hydrolases
    Microtubules
    Phosphotransferases
    Aurora Kinase B
    Enzymes

    Cite this

    Vallardi, G., Cordeiro, M. H., & Saurin, A. T. (2017). A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. In B. E. Black (Ed.), Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance (Vol. 56, pp. 457-484). (Progress in Molecular and Subcellular Biology; Vol. 56). Switzerland: Springer International Publishing. https://doi.org/10.1007/978-3-319-58592-5_19
    Vallardi, Giulia ; Cordeiro, Marilia Henriques ; Saurin, Adrian Thomas. / A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. editor / Ben E. Black. Vol. 56 Switzerland : Springer International Publishing, 2017. pp. 457-484 (Progress in Molecular and Subcellular Biology).
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    abstract = "The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.",
    author = "Giulia Vallardi and Cordeiro, {Marilia Henriques} and Saurin, {Adrian Thomas}",
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    Vallardi, G, Cordeiro, MH & Saurin, AT 2017, A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. in BE Black (ed.), Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. vol. 56, Progress in Molecular and Subcellular Biology, vol. 56, Springer International Publishing, Switzerland, pp. 457-484. https://doi.org/10.1007/978-3-319-58592-5_19

    A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. / Vallardi, Giulia; Cordeiro, Marilia Henriques; Saurin, Adrian Thomas (Lead / Corresponding author).

    Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. ed. / Ben E. Black. Vol. 56 Switzerland : Springer International Publishing, 2017. p. 457-484 (Progress in Molecular and Subcellular Biology; Vol. 56).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

    TY - CHAP

    T1 - A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC

    AU - Vallardi, Giulia

    AU - Cordeiro, Marilia Henriques

    AU - Saurin, Adrian Thomas

    N1 - © Springer International Publishing AG 2017.

    PY - 2017

    Y1 - 2017

    N2 - The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.

    AB - The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore. It integrates the activities of two kinases (MPS1 and Aurora B) and two phosphatases (PP1 and PP2A-B56) to regulate kinetochore-microtubule attachments and the spindle assembly checkpoint (SAC). We will first discuss each of these enzymes separately, to describe how they are regulated at kinetochores and why this is important for their primary function in controlling either microtubule attachments or the SAC. We will then discuss why inhibiting any one of them individually produces secondary effects on all the others. This cross-talk may help to explain why all enzymes have been linked to both processes, even though the direct evidence suggests they each control only one. This chapter therefore describes how a network of kinases and phosphatases work together to regulate two key mitotic processes.

    U2 - 10.1007/978-3-319-58592-5_19

    DO - 10.1007/978-3-319-58592-5_19

    M3 - Chapter (peer-reviewed)

    SN - 9783319585918

    VL - 56

    T3 - Progress in Molecular and Subcellular Biology

    SP - 457

    EP - 484

    BT - Centromeres and Kinetochores

    A2 - Black, Ben E.

    PB - Springer International Publishing

    CY - Switzerland

    ER -

    Vallardi G, Cordeiro MH, Saurin AT. A Kinase-Phosphatase Network that Regulates Kinetochore-Microtubule Attachments and the SAC. In Black BE, editor, Centromeres and Kinetochores: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance. Vol. 56. Switzerland: Springer International Publishing. 2017. p. 457-484. (Progress in Molecular and Subcellular Biology). https://doi.org/10.1007/978-3-319-58592-5_19