A level-set approach for a multi-scale cancer invasion model

Thomas Carraro (Lead / Corresponding author), Swen E. Wetterauer, Ana Victoria Ponce Bobadilla, Dumitru Trucu (Lead / Corresponding author)

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Abstract

The quest for a deeper understanding of the cancer growth and spread process focuses on the naturally multiscale nature of cancer invasion, which requires an appropriate multiscale modeling and analysis approach. The cross-talk between the dynamics of the cancer cell population on the tissue scale (macroscale) and the proteolytic molecular processes along the tumor border on the cell scale (microscale) plays a particularly important role within the invasion processes, leading to dramatic changes in tumor morphology and influencing the overall pattern of cancer spread.

Building on the multiscale moving boundary framework proposed in Trucu et al. [73] (Multiscale Model. Simul 11(1): 309-335), in this work we propose a new formulation of this process involving a novel derivation of the macro scale boundary movement law based on micro-dynamics, involving a transport equation combined with the level set method. This is explored numerically in a novel finite element macro-micro framework based on cut-cells.
Original languageEnglish
Number of pages23
JournalMathematics in Applied Sciences and Engineering
Early online date15 Mar 2021
DOIs
Publication statusE-pub ahead of print - 15 Mar 2021

Keywords

  • cancer invasion
  • multiscale modelling
  • level set
  • FEM
  • cut-cells

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