A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients

Roma Maguire, Donald C. McMillan, A. Michael Wallace, Colin McArdle

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.
    Original languageEnglish
    Pages (from-to)174-177
    Number of pages4
    JournalCytokine
    Volume20
    Issue number4
    DOIs
    Publication statusPublished - Nov 2002

    Keywords

    • Colorectal liver metastases
    • Leptin
    • Appetite
    • Energy
    • Metabolism
    • Body fat mass

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