A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients

Roma Maguire; Donald C. McMillan; A. Michael Wallace; Colin McArdle

doi:10.1006/cyto.2002.1995

A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients

Roma Maguire, Donald C. McMillan, A. Michael Wallace, Colin McArdle

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.

Original language	English
Pages (from-to)	174-177
Number of pages	4
Journal	Cytokine
Volume	20
Issue number	4
DOIs	https://doi.org/10.1006/cyto.2002.1995
Publication status	Published - Nov 2002

Keywords

Colorectal liver metastases
Leptin
Appetite
Energy
Metabolism
Body fat mass

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/cyto.2002.1995

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title = "A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients",

abstract = "Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.",

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author = "Roma Maguire and McMillan, {Donald C.} and Wallace, {A. Michael} and Colin McArdle",

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T1 - A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients

AU - Maguire, Roma

AU - McMillan, Donald C.

AU - Wallace, A. Michael

AU - McArdle, Colin

PY - 2002/11

Y1 - 2002/11

N2 - Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.

AB - Leptin and its relationship with energy metabolism in male weight-stable patients with colorectal liver metastases (n=14) was assessed at baseline and after 6 weeks. At baseline, median leptin concentration was 5.9 microg/l and the median percentage fat mass was 32.1%. Circulating leptin concentrations were correlated with measured percentage fat mass at baseline (r(s)=0.519, P=0.040) and with the changes after 6 weeks (r(s)=0.611, P=0.027) but not with insulin, cortisol, C-reactive protein, appetite or resting energy expenditure. Therefore, it would appear that leptin concentrations reflect changes in fat mass in male weight-stable patients with cancer and their role in the regulation of energy metabolism appears more complex than previously proposed.

KW - Colorectal liver metastases

KW - Leptin

KW - Appetite

KW - Energy

KW - Metabolism

KW - Body fat mass

U2 - 10.1006/cyto.2002.1995

DO - 10.1006/cyto.2002.1995

M3 - Article

C2 - 12543082

SN - 1043-4666

VL - 20

SP - 174

EP - 177

JO - Cytokine

JF - Cytokine

IS - 4

ER -

A longitudinal study of leptin and appetite, resting energy expenditure and body fat mass in weight-stable cancer patients

Abstract

Keywords

UN SDGs

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