A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

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• Finished

  Molecular Mechanisms of O-GICNAC Signalling (Investigator award)

  van Aalten, D. (Investigator)

  1/03/16 → 28/02/22

  Project: Research

  • Transferase 100%
  • O-GlcNAc Transferase 93%
  • O-GlcNAcylation 56%
  • Intellectual Disability 55%
  • O-linked N-acetylglucosamine (O-GlcNAc) 44%

• Genetic Structural and Chemical Validation of Aspergillus Fumigatus Cell Wall Targets (Programme Grant)

  van Aalten, D. (Investigator)

  1/11/14 → 31/10/19

  Project: Research

  • Aspergillus Fumigatus 100%
  • Enzyme 84%
  • Aspergillus fumigatus 67%
  • Cell Wall 61%
  • N-Acetylglucosamine 53%

• Protein Glycosylation in Trypanosomes: Defining and Exploiting a Biological System (Senior Investigator Award)

  Ferguson, M. (Investigator)

  1/10/13 → 30/06/23

  Project: Research

  • Trypanosoma Brucei 100%
  • GPI-anchored Protein (GPI-AP) 40%
  • Bloodstream Forms 37%
  • T. Brucei 35%
  • Trypanosoma 33%