Projects per year
Abstract
During vertebrate gastrulation, an embryo transforms from a layer of epithelial cells into a multilayered gastrula. This process requires the coordinated movements of hundreds to tens of thousands of cells, depending on the organism. In the chick embryo, patterns of actomyosin cables spanning several cells drive coordinated tissue flows. Here, we derive a minimal theoretical framework that couples actomyosin activity to global tissue flows. Our model predicts the onset and development of gastrulation flows in normal and experimentally perturbed chick embryos, mimicking different gastrulation modes as an active stress instability. Varying initial conditions and a parameter associated with active cell ingression, our model recapitulates distinct vertebrate gastrulation morphologies, consistent with recently published experiments in the chick embryo. Altogether, our results show how changes in the patterning of critical cell behaviors associated with different force-generating mechanisms contribute to distinct vertebrate gastrulation modes via a self-organizing mechanochemical process.
Original language | English |
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Article number | eadh8152 |
Number of pages | 11 |
Journal | Science Advances |
Volume | 9 |
Issue number | 49 |
Early online date | 6 Dec 2023 |
DOIs | |
Publication status | E-pub ahead of print - 6 Dec 2023 |
ASJC Scopus subject areas
- General
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Investigation of Mechanics of Gastrulation Using New Transgenic Lines
Weijer, K. (Investigator)
Biotechnology and Biological Sciences Research Council
1/01/20 → 31/12/24
Project: Research
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Acquisition of a TriSpim Lightsheet Microscope
Gartner, A. (Investigator), Januschke, J. (Investigator), MacDonald, M. (Investigator), Nathke, I. (Investigator), Storey, K. (Investigator), Swedlow, J. (Investigator), Tanaka, T. (Investigator) & Weijer, K. (Investigator)
Biotechnology and Biological Sciences Research Council
15/08/17 → 14/08/18
Project: Research
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Epithelial Sheet Dynamics during Primitive Streak Formation as Active Matter (joint with University of Aberdeen)
Sknepnek, R. (Investigator) & Weijer, K. (Investigator)
Biotechnology and Biological Sciences Research Council
1/04/16 → 30/10/19
Project: Research
Research output
- 2 Citations
- 1 Preprint
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A mechanochemical model recapitulates distinct vertebrate gastrulation modes
Serra, M. (Lead / Corresponding author), Nájera, G. S., Chuai, M., Spandan, V., Weijer, C. J. & Mahadevan, L. (Lead / Corresponding author), 5 Oct 2021, BioRxiv, 24 p.Research output: Working paper/Preprint › Preprint