A Mitotic Role for BRCA1/BARD1 in Tumor Suppression?

Paul R. Clarke; Helen S. Sanderson

doi:10.1016/j.cell.2006.10.020

A Mitotic Role for BRCA1/BARD1 in Tumor Suppression?

Paul R. Clarke, Helen S. Sanderson

Research output: Contribution to journal › Short survey › peer-review

4 Citations (Scopus)

Abstract

The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.

Original language	English
Pages (from-to)	453-455
Number of pages	3
Journal	Cell
Volume	127
Issue number	3
Early online date	2 Nov 2006
DOIs	https://doi.org/10.1016/j.cell.2006.10.020
Publication status	Published - 3 Nov 2006

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

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10.1016/j.cell.2006.10.020Licence: Elsevier User Licence

Cite this

@article{73404905052549e5975ed97f872445db,

title = "A Mitotic Role for BRCA1/BARD1 in Tumor Suppression?",

abstract = "The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.",

author = "Clarke, {Paul R.} and Sanderson, {Helen S.}",

year = "2006",

month = nov,

day = "3",

doi = "10.1016/j.cell.2006.10.020",

language = "English",

volume = "127",

pages = "453--455",

journal = "Cell",

issn = "0092-8674",