A Mitotic Role for BRCA1/BARD1 in Tumor Suppression?

Paul R. Clarke, Helen S. Sanderson

    Research output: Contribution to journalShort survey

    3 Citations (Scopus)

    Abstract

    The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.

    Original languageEnglish
    Pages (from-to)453-455
    Number of pages3
    JournalCell
    Volume127
    Issue number3
    Early online date2 Nov 2006
    DOIs
    Publication statusPublished - 3 Nov 2006

    Fingerprint

    Tumor Suppressor Proteins
    Spindle Apparatus
    GTP Phosphohydrolases
    Tumors
    Carcinogenesis
    Neoplasms

    Cite this

    Clarke, Paul R. ; Sanderson, Helen S. / A Mitotic Role for BRCA1/BARD1 in Tumor Suppression?. In: Cell. 2006 ; Vol. 127, No. 3. pp. 453-455.
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    abstract = "The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.",
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    A Mitotic Role for BRCA1/BARD1 in Tumor Suppression? / Clarke, Paul R.; Sanderson, Helen S.

    In: Cell, Vol. 127, No. 3, 03.11.2006, p. 453-455.

    Research output: Contribution to journalShort survey

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