The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. (2006) demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.
|Number of pages||3|
|Early online date||2 Nov 2006|
|Publication status||Published - 3 Nov 2006|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)