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A molecular explanation for the recessive nature of
parkin
-linked Parkinson's disease
Donald E. Spratt
, R. Julio Martinez-Torres
, Yeong J. Noh
, Pascal Mercier
, Noah Manczyk
, Kathryn R. Barber
, Jacob D. Aguirre
, Lynn Burchell
, Andrew Purkiss
, Helen Walden (Lead / Corresponding author)
, Gary S. Shaw
Research output
:
Contribution to journal
›
Article
›
peer-review
116
Citations (Scopus)
Overview
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parkin
-linked Parkinson's disease'. Together they form a unique fingerprint.
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Keyphrases
Parkinson's Disease
100%
Parkin
100%
Autosomal Recessive
57%
Juvenile Parkinsonism
57%
Ubiquitin-like
28%
Pathogenic mutations
28%
RING E3 Ligase
28%
Amino
14%
Cysteine
14%
C-terminus
14%
Ubiquitination
14%
Ubiquitin
14%
UBE2T
14%
Carboxyl Terminus
14%
Single Surface
14%
In Cis
14%
Globular
14%
Conformation in Solution
14%
PARK2
14%
Biochemistry, Genetics and Molecular Biology
Autosomal Recessive Inheritance
100%
Ubiquitin
75%
C-Terminus
50%
Conformation
50%
Enzyme
25%
Solution and Solubility
25%
N-Terminus
25%
Ubiquitination
25%
Ubiquitin-Conjugating Enzyme
25%
Cysteine
25%
Ubiquitin Ligase
25%