A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

Sarmi Sri, Adam Greenstein, Alessandra Granata, Alex Collcutt, Angela C.C. Jochems, Barry W. McColl, Bianca Diaz Castro, Caleb Webber, Carmen Arteaga Reyes, Catherine Hall, Catherine B. Lawrence, Cheryl Hawkes, Chrysia-Maria Pegasiou-Davies, Claire Gibson, Colin L. Crawford, Colin Smith, Denis Vivien, Fiona H. McLean, Frances Wiseman, Gaia BrezzoGiovanna Lalli, Harry A. T. Pritchard, Hugh S. Markus, Isabel Bravo-Ferrer, Jade Taylor, James Leiper, Jason Berwick, Jian Gan, John Gallacher, Jonathan Moss, Jozien Goense, Letitia McMullan, Lorraine Work, Lowri Evans, Michael S. Stringer, M. L. J. Ashford, Mohamed Abulfadl, Nina Conlon, Paresh Malhotra, Philip Bath, Rebecca Canter, Rosalind Brown, Selvi Ince, Silvia Anderle, Simon Young, Sophie Quick, Stefan Szymkowiak, Steve Hill, Stuart Allan, Tao Wang, Terry Quinn, Tessa Procter, Tracy D. Farr, Xiangjun Zhao, Zhiyuan Yang, Atticus H. Hainsworth, Joanna M. Wardlaw (Lead / Corresponding author)

    Research output: Contribution to journalReview articlepeer-review

    1 Citation (Scopus)
    33 Downloads (Pure)


    Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

    Original languageEnglish
    Article number100189
    Number of pages12
    JournalCerebral Circulation - Cognition and Behavior
    Early online date11 Oct 2023
    Publication statusPublished - Oct 2023


    • Cerebral vascular disease
    • Dementia
    • Small vessel disease
    • Vascular cognitive impairment
    • Vascular dementia

    ASJC Scopus subject areas

    • Neurology
    • Cognitive Neuroscience
    • Clinical Neurology
    • Biological Psychiatry
    • Behavioral Neuroscience


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