A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase

Teresa L. McGuinness, Yvonne Lai, Paul Greengard, James R. Woodgett, Philip Cohen

    Research output: Contribution to journalArticle

    89 Citations (Scopus)

    Abstract

    Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca2+ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.

    Original languageEnglish
    Pages (from-to)329-334
    Number of pages6
    JournalFEBS Letters
    Volume163
    Issue number2
    DOIs
    Publication statusPublished - 14 Nov 1983

    Keywords

    • Ca
    • Calmodulin
    • Protein phosphorylation

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