A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase

Teresa L. McGuinness; Yvonne Lai; Paul Greengard; James R. Woodgett; Philip Cohen

doi:10.1016/0014-5793(83)80846-1

A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase

Teresa L. McGuinness, Yvonne Lai, Paul Greengard, James R. Woodgett, Philip Cohen

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca²⁺ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.

Original language	English
Pages (from-to)	329-334
Number of pages	6
Journal	FEBS Letters
Volume	163
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(83)80846-1
Publication status	Published - 14 Nov 1983

Keywords

Ca
Calmodulin
Protein phosphorylation

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

Access to Document

10.1016/0014-5793(83)80846-1Licence: No Licence / Unknown

Cite this

@article{cf2b6352872d44aab98af72782f4ad78,

title = "A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase",

abstract = "Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca2+ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.",

keywords = "Ca, Calmodulin, Protein phosphorylation",

author = "McGuinness, \{Teresa L.\} and Yvonne Lai and Paul Greengard and Woodgett, \{James R.\} and Philip Cohen",

year = "1983",

month = nov,

day = "14",

doi = "10.1016/0014-5793(83)80846-1",

language = "English",

volume = "163",

pages = "329--334",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase

AU - McGuinness, Teresa L.

AU - Lai, Yvonne

AU - Greengard, Paul

AU - Woodgett, James R.

AU - Cohen, Philip

PY - 1983/11/14

Y1 - 1983/11/14

N2 - Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca2+ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.

AB - Calmodulin-dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site-specificities, immunological cross-reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin-dependent protein kinase that mediates many of the actions of Ca2+ in various tissues. Therefore, we propose the name 'calmodulin-dependent multi-protein kinase' for this broad specificity enzyme.

KW - Ca

KW - Calmodulin

KW - Protein phosphorylation

UR - https://www.scopus.com/pages/publications/0021077430

U2 - 10.1016/0014-5793(83)80846-1

DO - 10.1016/0014-5793(83)80846-1

M3 - Article

C2 - 6315492

AN - SCOPUS:0021077430

SN - 0014-5793

VL - 163

SP - 329

EP - 334

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

A multifunctional calmodulin-dependent protein kinase. Similarities between skeletal muscle glycogen synthase kinase and a brain synapsin I kinase

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this