A nano-mechanical study on the influence of ultrasound exposure on cellular elasticity

Michael Conneely, David McGloin, Pamela Robertson, W. H.Irwin McLean, Paul Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

For the purposes of the present study, we are attempting to improve the understanding of the cell-mechanical bioeffects that US exposure promotes. Here we undertake targeted live cell force spectroscopy measurements exploring the induced elasticity changes in MCF-7 human breast cancer cells with varying incident US power. Stiffness, as measured both on and off-nucleus, appears to respond rapidly to US exposure, maximally doubling from quiescent values within 300s in some cases. We also note however that each geometric arrangement of the target cell within its local grouping must be considered on its own merits as the stabilizing effect of its nearest neighbours may influence net measurements.

Original languageEnglish
Title of host publication2013 IEEE International Ultrasonics Symposium, IUS 2013
Place of PublicationUSA
PublisherIEEE
Pages390-392
Number of pages3
ISBN (Print)9781467356862
DOIs
Publication statusPublished - 2013
Event2013 IEEE International Ultrasonics Symposium, IUS 2013 - Prague, Czech Republic
Duration: 21 Jul 201325 Jul 2013

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2013 IEEE International Ultrasonics Symposium, IUS 2013
Country/TerritoryCzech Republic
CityPrague
Period21/07/1325/07/13

Keywords

  • AFM
  • Cellular elasticity
  • Force spectrscopy
  • Ultrasound

Fingerprint

Dive into the research topics of 'A nano-mechanical study on the influence of ultrasound exposure on cellular elasticity'. Together they form a unique fingerprint.

Cite this