A neural protection racket: AMPK and the GABAB receptor

D. Grahame Hardie, Bruno G. Frenguelli

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    The cellular energy-sensing kinase AMPK is known to be activated in neurons in response to metabolic insults, but the downstream consequences have been unclear. A study by Kuramoto and colleagues in this issue of Neuron favors the idea that AMPK activation is neuroprotective, and suggests a potential mechanism for this effect involving phosphorylation of the GABA(B) receptor.
    Original languageEnglish
    Pages (from-to)159-162
    Number of pages4
    JournalNeuron
    Volume53
    Issue number2
    DOIs
    Publication statusPublished - 18 Jan 2007

    Keywords

    • AMP-Activated Protein Kinases
    • Animals
    • Cytoprotection
    • Enzyme Activation
    • Multienzyme Complexes
    • Neurons
    • Phosphorylation
    • Protein-Serine-Threonine Kinases
    • Receptors, GABA-B

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