The cellular energy-sensing kinase AMPK is known to be activated in neurons in response to metabolic insults, but the downstream consequences have been unclear. A study by Kuramoto and colleagues in this issue of Neuron favors the idea that AMPK activation is neuroprotective, and suggests a potential mechanism for this effect involving phosphorylation of the GABA(B) receptor.
- AMP-Activated Protein Kinases
- Enzyme Activation
- Multienzyme Complexes
- Protein-Serine-Threonine Kinases
- Receptors, GABA-B