A neural protection racket: AMPK and the GABAB receptor

D. Grahame Hardie; Bruno G. Frenguelli

doi:10.1016/j.neuron.2007.01.004

A neural protection racket: AMPK and the GABA_B receptor

D. Grahame Hardie, Bruno G. Frenguelli

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The cellular energy-sensing kinase AMPK is known to be activated in neurons in response to metabolic insults, but the downstream consequences have been unclear. A study by Kuramoto and colleagues in this issue of Neuron favors the idea that AMPK activation is neuroprotective, and suggests a potential mechanism for this effect involving phosphorylation of the GABA(B) receptor.

Original language	English
Pages (from-to)	159-162
Number of pages	4
Journal	Neuron
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2007.01.004
Publication status	Published - 18 Jan 2007

Keywords

AMP-Activated Protein Kinases
Animals
Cytoprotection
Enzyme Activation
Multienzyme Complexes
Neurons
Phosphorylation
Protein-Serine-Threonine Kinases
Receptors, GABA-B

Access to Document

10.1016/j.neuron.2007.01.004

Cite this

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abstract = "The cellular energy-sensing kinase AMPK is known to be activated in neurons in response to metabolic insults, but the downstream consequences have been unclear. A study by Kuramoto and colleagues in this issue of Neuron favors the idea that AMPK activation is neuroprotective, and suggests a potential mechanism for this effect involving phosphorylation of the GABA(B) receptor.",

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KW - Animals

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KW - Enzyme Activation

KW - Multienzyme Complexes

KW - Neurons

KW - Phosphorylation

KW - Protein-Serine-Threonine Kinases

KW - Receptors, GABA-B

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