A new haplotype of PDCD1 is associated with rheumatoid arthritis in Hong Kong Chinese

Eric Kai-Pang Kong, Ludmila Prokunina-Olsson, Wilfred Hing-Sang Wong, Chak-Sing Lau, Tak-Mao Chan, Marta Alarcon-Riquelme, Yu-Lung Lau

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    116 Citations (Scopus)

    Abstract

    Objective The programmed death 1 (PD-1) molecule is a negative regulator of T cells, and a genetic association between PD-1 and systemic lupus erythematosus and rheumatoid arthritis (RA) in Caucasians has been reported. The aim of this study was to investigate the association of PDCD1 polymorphisms and haplotypes with RA in the Chinese population. Methods Three single-nucleotide polymorphisms (SNPs), PD-1.1 G/A, PD-1.3 G/A, and PD-1.5 C/T, were genotyped in 180 patients with RA and 647 healthy controls in a case–control association study. Analyses of the association of genotypes and alleles with disease, haplotype construction, and linkage disequilibrium (LD) were performed. Results We constructed haplotypes with the alleles of markers PD-1.1 G/A and PD-1.5 C/T and found that the GT haplotype was overrepresented in patients with RA (31%) compared with controls (23%) (P = 0.001, odds ratio [OR] 1.54, 95% confidence interval [95% CI] 1.18–1.99). Among GT double homozygotes the risk of RA was increased even further (OR 2.31, 95% CI 1.31–4.08, P = 0.006). We also observed that the AA genotype of SNP PD-1.1 was associated with a decreased risk for developing RA (OR 0.38, 95% CI 0.15–0.99, P = 0.034). No association for SNP PD-1.5 in RA was found, and SNP PD-1.3 was nonpolymorphic in the Chinese population. Conclusion Our results support the involvement of PDCD1 as a susceptibility gene for RA in the Chinese population. © 2005, American College of Rheumatology
    Original languageEnglish
    Pages (from-to)1058-1062
    Number of pages5
    JournalArthritis & Rheumatism
    Volume52
    Issue number4
    DOIs
    Publication statusPublished - Apr 2005

    Keywords

    • Rheumatoid arthritis
    • Programmed death 1 (PD-1) molecule
    • PD-1
    • Systemic lupus erythematosus
    • Genetic predisposition to disease
    • Haplotypes genetics
    • Polymorphism

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