A nomenclature for ligand-gated ion channels

Graham L. Collingridge; Richard W. Olsen; John Peters; Michael Spedding

doi:10.1016/j.neuropharm.2008.06.063

A nomenclature for ligand-gated ion channels

Graham L. Collingridge, Richard W. Olsen, John Peters, Michael Spedding

Research output: Contribution to journal › Article › peer-review

476 Citations (Scopus)

Abstract

The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine(3) (5-HT3), gamma-aminobutyric acid(A) (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely. to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues. (C) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	25
Number of pages	4
Journal	Neuropharmacology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1016/j.neuropharm.2008.06.063
Publication status	Published - Jan 2009

Keywords

Ligand-gated ion channels
Nomenclature
UNION-OF-PHARMACOLOGY
GLUTAMATE RECEPTOR SUBUNIT
INTERNATIONAL-UNION
MOLECULAR RELATIONSHIPS
POTASSIUM CHANNELS
NMDA RECEPTOR
CLONING
GENES
CLASSIFICATION
EXPRESSION

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10.1016/j.neuropharm.2008.06.063

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title = "A nomenclature for ligand-gated ion channels",

abstract = "The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine(3) (5-HT3), gamma-aminobutyric acid(A) (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely. to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues. (C) 2008 Elsevier Ltd. All rights reserved.",

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author = "Collingridge, {Graham L.} and Olsen, {Richard W.} and John Peters and Michael Spedding",

year = "2009",

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AU - Collingridge, Graham L.

AU - Olsen, Richard W.

AU - Peters, John

AU - Spedding, Michael

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N2 - The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine(3) (5-HT3), gamma-aminobutyric acid(A) (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely. to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues. (C) 2008 Elsevier Ltd. All rights reserved.

AB - The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine(3) (5-HT3), gamma-aminobutyric acid(A) (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely. to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues. (C) 2008 Elsevier Ltd. All rights reserved.

KW - Ligand-gated ion channels

KW - Nomenclature

KW - UNION-OF-PHARMACOLOGY

KW - GLUTAMATE RECEPTOR SUBUNIT

KW - INTERNATIONAL-UNION

KW - MOLECULAR RELATIONSHIPS

KW - POTASSIUM CHANNELS

KW - NMDA RECEPTOR

KW - CLONING

KW - GENES

KW - CLASSIFICATION

KW - EXPRESSION

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DO - 10.1016/j.neuropharm.2008.06.063

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SN - 0028-3908

VL - 56

SP - 25

JO - Neuropharmacology

JF - Neuropharmacology

IS - 1

ER -

A nomenclature for ligand-gated ion channels

Abstract

Keywords

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