A normalised scale for structural genomics target ranking: the OB-Score

Ian M. Overton, Geoffrey J. Barton (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Target selection and ranking is fundamental to structural genomics. We present a Z-score scale, the "OB-Score", to rank potential targets by their predicted propensity to produce diffraction-quality crystals. The OB-Score is derived from a matrix of predicted isoelectric point and hydrophobicity values for nonredundant PDB entries solved to <or=3.0 A against a background of UniRef50. A highly significant difference was found between the OB-Scores for TargetDB test datasets. A wide range of OB-Scores was observed across 241 proteomes and within 7868 PfamA families; 73.4% of PfamA families contain >or=1 member with a high OB-Score, presenting favourable candidates for structural studies.

Original languageEnglish
Pages (from-to)4005-4009
Number of pages5
JournalFEBS Letters
Volume580
Issue number16
Early online date16 Jun 2006
DOIs
Publication statusPublished - 10 Jul 2006

Keywords

  • Databases, Protein
  • Genomics
  • Hydrophobic and hydrophilic Interactions
  • Isoelectric point
  • Proteins
  • Statistics as topic

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