A novel allosteric inhibitor of the uridine diphosphate N-acetylglucosamine pyrophosphorylase from Trypanosoma brucei

Keyphrases

• Trypanosoma Brucei 100%
• Allosteric Inhibitor 100%
• Pyrophosphatase 100%
• Uridine Diphosphate N-acetylglucosamine 100%
• N-acetylglucosamine 60%
• T. Brucei 40%
• Human African Trypanosomiasis 20%
• Recombinant 20%
• Human Homolog 20%
• High-throughput Screening 20%
• Conformational Rearrangement 20%
• Trypanosome 20%
• Therapeutic Potential 20%
• Substrate Binding 20%
• UDP-GlcNAc 20%
• Binding Residues 20%
• Inhibitor Complex 20%
• Competitive Inhibitor 20%
• Structural Characterization 20%
• Etiological Agents 20%
• Essential Metabolite 20%
• Biophysical Characterization 20%
• Allosteric Site 20%
• Enzyme Kinetics 20%
• Ordered Bi-bi Mechanism 20%
• Allosteric Binding Site 20%

Biochemistry, Genetics and Molecular Biology

• Trypanosoma Brucei 100%
• N-Acetylglucosamine 100%
• Uridine Diphosphate N-Acetylglucosamine 100%
• Enzyme 66%
• Uridine Triphosphate 66%
• Binding Site 33%
• Anabolism 33%
• Trypanosoma 33%
• Metabolite 33%
• Active Site 33%
• Uridine Diphosphate 33%
• High Throughput Screening 33%
• Enzyme Kinetics 33%
• Competitive Inhibition 33%
• Allosteric Site 33%

Immunology and Microbiology

• Trypanosoma Brucei 100%
• Binding Site 50%
• Trypanosoma 50%
• Metabolite 50%
• High Throughput Screening 50%
• Competitive Inhibition 50%
• Enzyme Kinetics 50%
• Allosteric Site 50%