A novel breath-actuated integrated vortex spacer device increases relative lung bioavailability of fluticasone/salmeterol in combination

Keyphrases

• Salmeterol 100%
• Fluticasone Propionate 100%
• Breath-actuated 100%
• Relative Lung Bioavailability 100%
• Synchro 100%
• Vortex 100%
• Spacer Device 100%
• Respirable 37%
• Lung 25%
• Hydrofluoroalkane 25%
• Urinary Cortisol 25%
• Creatinine 25%
• Dose Delivery 25%
• Serum Potassium 25%
• Seretide 25%
• Relative Bioavailability 25%
• No Significant Difference 12%
• Drug Delivery 12%
• Nineteen 12%
• Healthy Volunteers 12%
• Geometric Mean 12%
• Large Volume 12%
• Placebo 12%
• Double Dummy 12%
• Adrenal Suppression 12%
• Randomized Double-blind 12%
• Dependant 12%
• Crossover Design 12%
• Total Dose 12%
• Arithmetic Mean 12%
• Surrogate Marker 12%
• Inhaled Fluticasone 12%
• β2-adrenoceptor 12%
• Anti-static 12%
• Vortex Chamber 12%
• Lung Dose 12%

Pharmacology, Toxicology and Pharmaceutical Science

• Bioavailability 100%
• Salmeterol 100%
• Fluticasone 100%
• Metered-Dose Inhaler 100%
• Isotopes of Potassium 40%
• Fluorinated Hydrocarbon 40%
• Hydrocortisone 40%
• Fluticasone Propionate Plus Salmeterol Xinafoate 40%
• Creatinine 40%
• Placebo 20%
• Normal Human 20%
• Beta 2 Adrenergic Receptor 20%
• Disease Marker 20%