A novel excitation-emission wavelength model to facilitate the diagnosis of urinary bladder diseases

Ilya Rafailov, Scott Palmer, Karina Litvinova, Victor Dremin, Andrey Dunaev, Ghulam Nabi

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    12 Citations (Scopus)

    Abstract

    Diseases of urinary bladder are a common healthcare problem world over. Diagnostic precision and predicting response to treatment are major issues. This study aims to create an optical cross-sectionional model of a bladder, capable of visually representing the passage of photons through the tissue layers. The absorption, transmission and reflectance data, along with the derived transmission coefficients (of scattering and absorption) were obtained from literature analysis and were used in the creation of a "generic" cross-section optical property model simulating the passage of thousands of photons through the tissue at different wavelengths. Fluorescence spectra of diagnostically relevant biomarkers excited by the UV and blue wavelengths were modelled on the basis of the Monte-Carlo method. Further to this, fluorescence data gathered by the "LAKK-M" system from pig bladders was applied to the model for a specific representation of the photon passage through the tissues. The ultimate goal of this study is to employ this model to simulate the effects of different laser wavelength and energy inputs to bladder tissue and to determine the effectiveness of potential photonics based devices for the diagnosis of bladder pathologies. The model will aid in observing differences between healthy and pathological bladder tissues registered by photonics based devices.

    Original languageEnglish
    Title of host publicationPhotonic Therapeutics and Diagnostics XI
    EditorsBernard Choi, Nikiforos Kollias, Haishan Zeng, Hyun Wook Kang, Brian J. F. Wong, Justus F. Ilgner, Alfred Nuttal, Claus-Peter Richter, Melissa C. Skala, Mark W. Dewhirst, Guillermo J. Tearney, Kenton W. Gregory, Laura Marcu, Andreas Mandelis, Michael D. Morris
    Place of PublicationBellingham
    PublisherSPIE-International Society for Optical Engineering
    ISBN (Print)9781628413939
    DOIs
    Publication statusPublished - 2015
    EventSPIE Photonics West 2014: Photonic Therapeutics and Diagnostics XI - The Moscone Center, San Francisco, United States
    Duration: 7 Feb 20158 Feb 2015
    http://spie.org/x112639.xml

    Publication series

    NameProceedings of SPIE
    PublisherSPIE
    Volume9303

    Conference

    ConferenceSPIE Photonics West 2014: Photonic Therapeutics and Diagnostics XI
    CountryUnited States
    CitySan Francisco
    Period7/02/158/02/15
    Internet address

    Keywords

    • Bladder cancer
    • Fluorescence spectroscopy
    • Modelling
    • Monte Carlo simulation
    • Non-invasive diagnostics

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