A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy

Paul O'Mahoney, Neil Haigh, Kenny Wood, C. Tom A. Brown, Sally Ibbotson, Ewan Eadie

Research output: Contribution to journalArticle

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Abstract

Objectives: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge.

Methods: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match. The uniformity of the light source is characterised on a flat surface, a model head and a model leg. For context, a typical conventional PDT light source is also characterised. Additionally, the wavelength uniformity across the treatment site is characterised.

Results: The PpIX-weighted spectrum of the novel light source matches with PpIX-weighted daylight spectrum, with irradiance values within the bounds for effective dPDT. By tuning the direction of light emission, improvements are seen in the uniformity across large anatomical surfaces. Wavelength uniformity is discussed.

Conclusions: We have developed a light source that addresses the challenges in uniform, multiwavelength light distribution for large area artificial dPDT across curved anatomical surfaces.

Original languageEnglish
Pages (from-to)144-150
Number of pages7
JournalPhotodiagnosis and photodynamic therapy
Volume23
Early online date18 Jun 2018
DOIs
Publication statusPublished - Sep 2018

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Photochemotherapy
Light
Weather
Leg
Therapeutics
Head

Keywords

  • Actinic keratosis
  • Light source
  • PDT
  • Photodynamic therapy
  • Uniformity

Cite this

@article{a4676b6ab62c4d48934028f672cd25b4,
title = "A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy",
abstract = "Objectives: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge.Methods: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match. The uniformity of the light source is characterised on a flat surface, a model head and a model leg. For context, a typical conventional PDT light source is also characterised. Additionally, the wavelength uniformity across the treatment site is characterised.Results: The PpIX-weighted spectrum of the novel light source matches with PpIX-weighted daylight spectrum, with irradiance values within the bounds for effective dPDT. By tuning the direction of light emission, improvements are seen in the uniformity across large anatomical surfaces. Wavelength uniformity is discussed.Conclusions: We have developed a light source that addresses the challenges in uniform, multiwavelength light distribution for large area artificial dPDT across curved anatomical surfaces.",
keywords = "Actinic keratosis, Light source, PDT, Photodynamic therapy, Uniformity",
author = "Paul O'Mahoney and Neil Haigh and Kenny Wood and Brown, {C. Tom A.} and Sally Ibbotson and Ewan Eadie",
note = "This project was supported by the University of St. Andrews through the Science and Technology Facilities Council (STFC) Impact Accelerator Award (IAA) and by the Laser Research and Therapy Fund (registered charity SC030850). P O’M is funded by Medi-lase (registered charity SC 037390) and the Alfred Stewart Trust.",
year = "2018",
month = "9",
doi = "10.1016/j.pdpdt.2018.06.013",
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journal = "Photodiagnosis and Photodynamic Therapy",
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A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy. / O'Mahoney, Paul; Haigh, Neil; Wood, Kenny; Brown, C. Tom A.; Ibbotson, Sally; Eadie, Ewan.

In: Photodiagnosis and photodynamic therapy, Vol. 23, 09.2018, p. 144-150.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A novel light source with tuneable uniformity of light distribution for artificial daylight photodynamic therapy

AU - O'Mahoney, Paul

AU - Haigh, Neil

AU - Wood, Kenny

AU - Brown, C. Tom A.

AU - Ibbotson, Sally

AU - Eadie, Ewan

N1 - This project was supported by the University of St. Andrews through the Science and Technology Facilities Council (STFC) Impact Accelerator Award (IAA) and by the Laser Research and Therapy Fund (registered charity SC030850). P O’M is funded by Medi-lase (registered charity SC 037390) and the Alfred Stewart Trust.

PY - 2018/9

Y1 - 2018/9

N2 - Objectives: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge.Methods: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match. The uniformity of the light source is characterised on a flat surface, a model head and a model leg. For context, a typical conventional PDT light source is also characterised. Additionally, the wavelength uniformity across the treatment site is characterised.Results: The PpIX-weighted spectrum of the novel light source matches with PpIX-weighted daylight spectrum, with irradiance values within the bounds for effective dPDT. By tuning the direction of light emission, improvements are seen in the uniformity across large anatomical surfaces. Wavelength uniformity is discussed.Conclusions: We have developed a light source that addresses the challenges in uniform, multiwavelength light distribution for large area artificial dPDT across curved anatomical surfaces.

AB - Objectives: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge.Methods: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match. The uniformity of the light source is characterised on a flat surface, a model head and a model leg. For context, a typical conventional PDT light source is also characterised. Additionally, the wavelength uniformity across the treatment site is characterised.Results: The PpIX-weighted spectrum of the novel light source matches with PpIX-weighted daylight spectrum, with irradiance values within the bounds for effective dPDT. By tuning the direction of light emission, improvements are seen in the uniformity across large anatomical surfaces. Wavelength uniformity is discussed.Conclusions: We have developed a light source that addresses the challenges in uniform, multiwavelength light distribution for large area artificial dPDT across curved anatomical surfaces.

KW - Actinic keratosis

KW - Light source

KW - PDT

KW - Photodynamic therapy

KW - Uniformity

U2 - 10.1016/j.pdpdt.2018.06.013

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