A novel protein extracted from foxtail millet bran displays anti-carcinogenic effects in human colon cancer cells

Shuhua Shan, Zongwei Li, Ian P. Newton, Chao Zhao, Zhuoyu Li (Lead / Corresponding author), Maolin Guo

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    Millet is an important cereal food and exhibits multiple biological activities, including immunomodulation, antioxidant, antifungal and anti-hyperglycemia effects. Herein, we describe a novel 35kDa protein with anti-cancer property, named FMBP, which was extracted and purified from foxtail millet bran by cell-based screening. FMBP is highly homologous to peroxidase as revealed by mass spectrometry and gene sequencing analysis. Furthermore, in vivo anti-tumor results implicated that the novel protein FMBP had the ability to suppress xenografted tumor growth in nude mice. Mechanistically, FMBP is able to suppress colon cancer cell growth through induction of G1 phase arrest and also causes a loss of mitochondrial transmembrane potential which results in caspase-dependent apoptosis in colon cancer cells. Notably, FMBP has much lower toxicity in normal colon epithelial cells. Taken together, FMBP has targeted anti-colon cancer effects and may serve as a therapeutic agent against colon cancer.
    Original languageEnglish
    Pages (from-to)129-138
    Number of pages10
    JournalToxicology Letters
    Volume227
    Issue number2
    DOIs
    Publication statusPublished - Jun 2014

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