A novel protein transport system involved in the biogenesis of bacterial electron transfer chains

Ben C. Berks, Frank Sargent, Erik De Leeuw, Andrew P. Hinsley, Nicola R. Stanley, Rachael L. Jack, Grant Buchanan, Tracy Palmer

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    36 Citations (Scopus)


    The Tat system is a recently discovered bacterial protein transport pathway that functions primarily in the biosynthesis of proteins containing redox active cofactors. Analogous transport systems are found in plant organelles. Remarkably and uniquely the Tat system functions to transported a diverse range of folded proteins across a biological membrane, a feat that must be achieved without rendering the membrane freely permeable to protons and other ions. Here we review the operation of the bacterial Tat system and propose a model for the structural organisation of the Tat preprotein translocase.
    Original languageEnglish
    Pages (from-to)325-30
    Number of pages6
    JournalBiochimica et Biophysica Acta (BBA) - Bioenergetics
    Issue number2-3
    Publication statusPublished - 2000


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