A novel protein transport system involved in the biogenesis of bacterial electron transfer chains

TY - JOUR

T1 - A novel protein transport system involved in the biogenesis of bacterial electron transfer chains

AU - Berks, Ben C.

AU - Sargent, Frank

AU - De Leeuw, Erik

AU - Hinsley, Andrew P.

AU - Stanley, Nicola R.

AU - Jack, Rachael L.

AU - Buchanan, Grant

AU - Palmer, Tracy

PY - 2000

Y1 - 2000

N2 - The Tat system is a recently discovered bacterial protein transport pathway that functions primarily in the biosynthesis of proteins containing redox active cofactors. Analogous transport systems are found in plant organelles. Remarkably and uniquely the Tat system functions to transported a diverse range of folded proteins across a biological membrane, a feat that must be achieved without rendering the membrane freely permeable to protons and other ions. Here we review the operation of the bacterial Tat system and propose a model for the structural organisation of the Tat preprotein translocase.

AB - The Tat system is a recently discovered bacterial protein transport pathway that functions primarily in the biosynthesis of proteins containing redox active cofactors. Analogous transport systems are found in plant organelles. Remarkably and uniquely the Tat system functions to transported a diverse range of folded proteins across a biological membrane, a feat that must be achieved without rendering the membrane freely permeable to protons and other ions. Here we review the operation of the bacterial Tat system and propose a model for the structural organisation of the Tat preprotein translocase.

U2 - 10.1016/S0005-2728(00)00168-7

DO - 10.1016/S0005-2728(00)00168-7

M3 - Article

C2 - 11004447

SN - 0005-2728

VL - 1459

SP - 325

EP - 330

JO - BBA - Bioenergetics

JF - BBA - Bioenergetics

IS - 2-3

ER -