A Perspective on the Use of NB-UVB Phototherapy vs. PUVA Photochemotherapy

Sally Ibbotson (Lead / Corresponding author)

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49 Citations (Scopus)
232 Downloads (Pure)


Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases. The main indication for NB-UVB and PUVA therapies is psoriasis, and other key diagnoses include atopic eczema, vitiligo, cutaneous T-cell lymphoma (CTCL), and the photodermatoses. The decision on choice of phototherapy is important and NB-UVB is usually the primary choice. NB-UVB phototherapy is a safe and effective therapy which is usually considered when topical agents have failed. PUVA requires prior psoralen sensitization but remains a highly effective mainstay therapy, often used when NB-UVB fails, there is rapid relapse following NB-UVB or in specific indications, such as pustular or erythrodermic psoriasis. This review will provide a perspective on the main indications for use of NB-UVB and PUVA therapies and provide comparative information on these important dermatological treatments.
Original languageEnglish
Article number184
Pages (from-to)1-8
Number of pages8
JournalFrontiers in Medicine
Publication statusPublished - 2 Jul 2018


  • UVB
  • PUVA therapy
  • phototherapy
  • skin diseases
  • psoriasis
  • ecsema
  • vitiligo


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