A pharmacodynamic model of the spindle assembly checkpoint and the action of the aurora kinase inhibitors

Keyphrases

• Abrogation 20%
• Anaphase 60%
• Aneuploidy 40%
• Aurora A 60%
• Aurora B 100%
• Aurora Kinase A (AURKA) 60%
• Aurora Kinase Inhibitor 100%
• Biological Processes 20%
• BubR1 20%
• CDC20 20%
• Cell Death 20%
• Cell Division 20%
• Chemotherapy 40%
• Chromosome Segregation 40%
• Defining Characteristic 20%
• Drug Target 20%
• Experimental Validation 20%
• Genetic Tumors 20%
• Genomic Instability 20%
• Histone H3 20%
• Invasive Phenotype 20%
• Kinetochore 100%
• Kinetochore-microtubule Attachment 20%
• Loss of Control 20%
• Mad2 20%
• Mechanistic Model 20%
• Merotelic Attachments 20%
• Metastatic Phenotype 20%
• Microtubules 40%
• Mitosis 20%
• Mitotic Defects 20%
• Mitotic Spindle Assembly 20%
• Modeling Approach 20%
• Non-selective 20%
• Pharmacodynamic Model 100%
• Phosphorylated Histone H3 40%
• PKPD Modeling 20%
• Polyploid Cells 20%
• Polyploidy 20%
• Premature Mitosis 20%
• Quantitative Characterization 20%
• Selective Inhibitor 60%
• Selective Treatment 20%
• Sister Chromatids 20%
• Specific Inhibitor 20%
• Spindle Assembly Checkpoint 100%
• Spindle Pole 20%
• Synergistic Drug Combination 20%
• Target Molecule 20%
• Treatment Strategy 20%
• Tumor 20%
• Tumor Progression 20%
• ZM447439 20%

Medicine and Dentistry

• Anaphase 60%
• Aneuploidy 40%
• Aurora A Kinase 60%
• Aurora B Kinase 60%
• Aurora Kinase Inhibitor 100%
• Biological Marker 20%
• Biological Phenomena and Functions Concerning the Entire Organism 20%
• Cell Death 20%
• Cell Division 20%
• Chemotherapy 40%
• Chromosome Segregation 40%
• Combination Drug 20%
• Histone H3 60%
• Kinetochore 100%
• Kinetochore Microtubule 20%
• Malignant Neoplasm 20%
• Microtubule 40%
• Mitosis Spindle 20%
• N [4 [6 Methoxy 7 (3 Morpholinopropoxy) 4 Quinazolinylamino]phenyl]benzamide 20%
• Neoplasm 20%
• Pharmacodynamics 100%
• Phosphotransferase 20%
• Polyploidy 40%
• Prematurity 20%
• Sister Chromatid 20%
• Spindle Checkpoint 100%
• Spindle Pole 20%
• Tumor Progression 20%

Biochemistry, Genetics and Molecular Biology

• Anaphase 50%
• Aneuploidy 33%
• Aurora A Kinase 50%
• Aurora B Kinase 50%
• Aurora Kinase 100%
• Biological Phenomena and Functions Concerning the Entire Organism 16%
• Cell Death 16%
• Cell Division 16%
• Chromosome Segregation 33%
• Genetics 16%
• Histone H3 50%
• Kinase 16%
• Kinetochore 100%
• Mitosis Spindle 16%
• Pharmacodynamics 100%
• Phosphotransferase 16%
• Polyploid 33%
• Sister Chromatid 16%
• Spindle Checkpoint 100%
• Syntelic 16%
• Tumor Progression 16%