A pivotal role for the response regulator DegU in controlling multicellular behaviour

Ewan J. Murray, Taryn B. Kiley, Nicola R. Stanley-Wall

    Research output: Contribution to journalReview articlepeer-review

    75 Citations (Scopus)

    Abstract

    Bacteria control multicellular behavioural responses, including biofilm formation and swarming motility, by integrating environmental cues through a complex regulatory network. Heterogeneous gene expression within an otherwise isogenic cell population that allows for differentiation of cell fate is an intriguing phenomenon that adds to the complexity of multicellular behaviour. This review focuses on recent data about how DegU, a pleiotropic response regulator, co-ordinates multicellular behaviour in Bacillus subtilis. We review studies that challenge the conventional understanding of the molecular mechanisms underpinning the DegU regulatory system and others that describe novel targets of DegU during activation of biofilm formation by B. subtilis. We also discuss a novel role for DegU in regulating multicellular processes in the food-borne pathogen Listeria monocytogenes.

    Original languageEnglish
    Pages (from-to)18
    Number of pages8
    JournalMicrobiology
    Volume155
    DOIs
    Publication statusPublished - Jan 2009

    Keywords

    • BACILLUS-SUBTILIS DEGU
    • DEGRADATIVE ENZYME-SYNTHESIS
    • GENOME-WIDE ANALYSIS
    • LISTERIA-MONOCYTOGENES
    • BIOFILM FORMATION
    • GENE-EXPRESSION
    • FLAGELLAR MOTILITY
    • POSITIVE REGULATOR
    • ACETYL PHOSPHATE
    • CELL FATE

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