A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

Tiara Ratz; Linda E Dean; Fabiola Atzeni; Christopher Reeks; Gary J Macfarlane; Tatiana Macfarlane

doi:10.1093/rheumatology/keu356

A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

Tiara Ratz, Linda E Dean, Fabiola Atzeni, Christopher Reeks, Gary J Macfarlane, Tatiana Macfarlane (Lead / Corresponding author)

Molecular and Clinical Medicine

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.

METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.

RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.

CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

Original language	English
Pages (from-to)	500-10
Number of pages	11
Journal	Rheumatology
Volume	54
Issue number	3
Early online date	10 Sept 2014
DOIs	https://doi.org/10.1093/rheumatology/keu356
Publication status	Published - Mar 2015

Keywords

Case-Control Studies
Humans
Periodontitis
Prevalence
Risk Factors
Spondylitis, Ankylosing
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review

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@article{82e915c30931419aaeb90ffb9a02d5ab,

title = "A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis",

abstract = "OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.",

keywords = "Case-Control Studies, Humans, Periodontitis, Prevalence, Risk Factors, Spondylitis, Ankylosing, Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Review",

author = "Tiara Ratz and Dean, {Linda E} and Fabiola Atzeni and Christopher Reeks and Macfarlane, {Gary J} and Tatiana Macfarlane",

note = "{\textcopyright} The Author 2014. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",

year = "2015",

month = mar,

doi = "10.1093/rheumatology/keu356",

language = "English",

volume = "54",

pages = "500--10",

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T1 - A possible link between ankylosing spondylitis and periodontitis

T2 - a systematic review and meta-analysis

AU - Ratz, Tiara

AU - Dean, Linda E

AU - Atzeni, Fabiola

AU - Reeks, Christopher

AU - Macfarlane, Gary J

AU - Macfarlane, Tatiana

PY - 2015/3

Y1 - 2015/3

N2 - OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

AB - OBJECTIVE: The aim of this study was to examine the link between AS and periodontitis.METHODS: Medline, Embase, AMED, CINAHL, Web of Science and Google Scholar were searched to identify eligible studies that were selected and reviewed independently by at least two authors.RESULTS: Six case-control studies were included in the review. Study size ranged from 90 to 40 926 participants. The prevalence of periodontitis ranged from 38% to 88% in AS patients and from 26% to 71% in controls. As there was low-level heterogeneity (I(2) = 13%), using fixed effects analysis the overall pooled estimate of the odds ratios for periodontitis was 1.85 (95% CI 1.72, 1.98). There was no evidence of publication bias.CONCLUSION: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

KW - Case-Control Studies

KW - Humans

KW - Periodontitis

KW - Prevalence

KW - Risk Factors

KW - Spondylitis, Ankylosing

KW - Journal Article

KW - Meta-Analysis

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1093/rheumatology/keu356

DO - 10.1093/rheumatology/keu356

M3 - Article

C2 - 25213130

SN - 1462-0324

VL - 54

SP - 500

EP - 510

JO - Rheumatology

JF - Rheumatology

IS - 3

ER -

A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

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Keywords

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